Dermal fillers: pathophysiology, prevention and treatment of complications

Dermal fillers are increasingly used for soft tissue augmentation of the face and hands. The widespread use of dermal fillers for rejuvenation has led to a rise in reports of associated complications. Although the majority of complications are mild and transient, serious and long‐lasting complicatio...

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Bibliographic Details
Published in:Journal of the European Academy of Dermatology and Venereology 2017-03, Vol.31 (3), p.405-413
Main Authors: Chiang, Y.Z., Pierone, G., Al‐Niaimi, F.
Format: Article
Language:English
Subjects:
Arterial Occlusive Diseases - chemically induced
Arterial Occlusive Diseases - complications
Arterial Occlusive Diseases - therapy
Dermal Fillers - adverse effects
Drug Hypersensitivity - etiology
Drug Hypersensitivity - therapy
Ecchymosis - chemically induced
Ecchymosis - therapy
Edema - chemically induced
Edema - therapy
Erythema - chemically induced
Erythema - therapy
Foreign-Body Reaction - chemically induced
Foreign-Body Reaction - therapy
Humans
Injections, Intradermal - adverse effects
Necrosis - etiology
Retinal Artery Occlusion - chemically induced
Retinal Artery Occlusion - therapy
Skin - pathology
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Summary:Dermal fillers are increasingly used for soft tissue augmentation of the face and hands. The widespread use of dermal fillers for rejuvenation has led to a rise in reports of associated complications. Although the majority of complications are mild and transient, serious and long‐lasting complications have been observed. This article discusses the key complications including pigmentary changes, hypersensitivity reactions, infections, nodule formation, granulomatous reactions, vascular occlusion and migration of filler material. A thorough literature review was performed in addition to the combined extensive authors’ (GP and FA) experience. Complications from fillers are increasingly being recognized and highlighted in the literature partly reflecting the growth in the market. This article provides a comprehensive overview of the filler complications with mechanisms of prevention and treatment per complication. A thorough understanding of the preventative and management strategies for the associated dermal filler complications will help the physician to prepare the patient well, and deal with complications that may arise effectively.
ISSN:0926-9959
1468-3083
DOI:10.1111/jdv.13977