Metabolic phenotyping of urine for discriminating alcohol-dependent from social drinkers and alcohol-naive subjects

Highlights • The orthogonal partial least square-discriminate analysis (OPLS-DA) revealed significant discrimination between alcohol-dependent (AD) and other groups. • The logistic regression analysis was able to identify six biomarkers in urine. • Metabolomics technique applied in urine was able to...

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Bibliographic Details
Published in:Drug and alcohol dependence 2016-12, Vol.169, p.80-84
Main Authors: Mostafa, Hamza, Amin, Arwa M, Teh, Chin-Hoe, Murugaiyah, Vikneswaran, Arif, Nor Hayati, Ibrahim, Baharudin, Dr
Format: Article
Language:English
Subjects:
Acids
Aconitic acid
Adult
Alanine
Alcohol
Alcohol Drinking - epidemiology
Alcohol Drinking - urine
Alcohol-dependence
Alcoholism
Alcoholism - diagnosis
Alcoholism - epidemiology
Alcoholism - urine
Alcohols
Analysis
Biological markers
Biomarker
Biomarkers
Biomarkers - urine
Citric acid
Correlation coefficient
Correlation coefficients
Cross-Sectional Studies
Data analysis
Data processing
Diagnosis
Discrimination
Drinking behavior
Female
Humans
Lactic acid
Magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy - methods
Malaysia - epidemiology
Male
Medical diagnosis
Metabolomics
Metabolomics - methods
Middle Aged
Multivariate analysis
NMR
Nuclear magnetic resonance
Phenotype
Phenotyping
Principal components analysis
Psychiatry
Public health
Questionnaires
Regression analysis
Reproducibility
Reproducibility of Results
Sensitivity
Spectroscopy
Urine
Urine tests
Valerates - urine
Young Adult
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Summary:Highlights • The orthogonal partial least square-discriminate analysis (OPLS-DA) revealed significant discrimination between alcohol-dependent (AD) and other groups. • The logistic regression analysis was able to identify six biomarkers in urine. • Metabolomics technique applied in urine was able to discriminate AD from other groups.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2016.10.016