IL-22 mediates the oral mucosal wound healing via STAT3 in keratinocytes

Highlights • IL-22 and STAT3 were involved in oral mucosal wound healing, and the value change tendency of Il-22 and STAT3 during the wound healing was similar. • STAT3 was activated after the keratinocytes or the tongue tissue were stimulated by IL-22,. • IL-22 could obviously promote the prolifera...

Full description

Saved in:
Bibliographic Details
Published in:Archives of oral biology 2016-12, Vol.72, p.14-20
Main Authors: Yu, Ran, Ding, Yumei, Zhu, Lijuan, Qu, Yinying, Zhang, Chenguang, Liu, Lin, Chen, Lili
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Blotting, Western
Cell Movement - physiology
Cell Proliferation - physiology
Collagen Type I - metabolism
Dentistry
Disease Models, Animal
Electrophoresis, Polyacrylamide Gel
Fibroblasts - physiology
IL-22
Immunohistochemistry
Interleukin-22
Interleukins - physiology
Keratinocytes - physiology
Matrix Metalloproteinase 1 - metabolism
Mice
Real-Time Polymerase Chain Reaction
STAT3
STAT3 Transcription Factor - physiology
Tongue - injuries
Wound healing
Wound Healing - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • IL-22 and STAT3 were involved in oral mucosal wound healing, and the value change tendency of Il-22 and STAT3 during the wound healing was similar. • STAT3 was activated after the keratinocytes or the tongue tissue were stimulated by IL-22,. • IL-22 could obviously promote the proliferation of keratinocytes, but not fibroblasts. • IL-22 could mediate gene expression in keratinocytes, such as type I collagen and MMP-1 which may contribute to re-epithelialization and scarless healing in oral wound healing.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2016.08.001