Hormonal and testicular changes in rats submitted to congenital hypothyroidism in early life

The goal of this study was to evaluate the influence of hypothyroidism induced by MMI, during gestation (G) or gestation plus lactation (GL) on testis and its relation with leptin in rats. Six to eight pups were killed at 90 days of age. For statistical analysis One-way ANOVA followed by the Holm-Sì...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2017-01, Vol.439, p.65-73
Main Authors: Aiceles, Veronica, Gombar, Flavia, da Fonte Ramos, Cristiane
Format: Article
Language:English
Subjects:
Animals
Body Weight
Congenital Hypothyroidism - blood
Congenital Hypothyroidism - metabolism
Congenital Hypothyroidism - pathology
Feeding Behavior
Female
Fertility
Fertility - genetics
Gene Expression Regulation
Hormones - blood
Hormones - metabolism
Hypothyroidism
Lactation
Leptin
Male
Models, Biological
Pregnancy
Rats, Wistar
Spermatozoa - metabolism
Testis
Testis - metabolism
Testis - pathology
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Summary:The goal of this study was to evaluate the influence of hypothyroidism induced by MMI, during gestation (G) or gestation plus lactation (GL) on testis and its relation with leptin in rats. Six to eight pups were killed at 90 days of age. For statistical analysis One-way ANOVA followed by the Holm-Sìdak post hoc test was used. Hypothyroidism resulted in a significant reduction in LH, FSH and testosterone and an increase in leptin serum levels (p 
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2016.10.026