The role of microRNA in periodontal tissue: A review of the literature

Highlights • Bone remodeling and inflammatory mediators orchestrate periodontal tissue pathogenesis. • MicroRNAs modulate RANKL and inflammatory mediator in periodontal resident cells such as gingival fibroblast and periodontal ligament cells. • MicroRNA profiling on diseased periodontal tissue demo...

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Bibliographic Details
Published in:Archives of oral biology 2016-12, Vol.72, p.66-74
Main Authors: Irwandi, Rizky Aditiya, Vacharaksa, Anjalee
Format: Article
Language:English
Subjects:
Advanced Basic Science
Alveolar Bone Loss - genetics
Alveolar Bone Loss - physiopathology
Biomarkers - metabolism
Bone remodeling
Bone Remodeling - genetics
Bone Remodeling - physiology
Dentistry
Humans
Inflammation Mediators - metabolism
Inflammatory mediators
MicroRNA
MicroRNAs - physiology
Osteoprotegerin - metabolism
Periodontal Diseases - genetics
Periodontal Diseases - physiopathology
Periodontal tissue
RANK Ligand - metabolism
RANKL
Receptor Activator of Nuclear Factor-kappa B - metabolism
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Summary:Highlights • Bone remodeling and inflammatory mediators orchestrate periodontal tissue pathogenesis. • MicroRNAs modulate RANKL and inflammatory mediator in periodontal resident cells such as gingival fibroblast and periodontal ligament cells. • MicroRNA profiling on diseased periodontal tissue demonstrates consistent identification of miR-223 indicating its potency to be further investigated in periodontitis-related processes.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2016.08.014