Genetic variation in leptin and leptin receptor genes as a risk factor for idiopathic male infertility

Summary The aim of this study was to examine whether there is an association among genetic variability in leptin (LEP) and leptin receptor (LEPR) genes and male infertility. We performed a case–control study and were searching for an association between polymorphisms of LEP and LEPR genes and male i...

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Published in:Andrology (Oxford) 2017-01, Vol.5 (1), p.70-74
Main Authors: Hodžić, A., Ristanović, M., Zorn, B., Tulić, C., Maver, A., Novaković, I., Plaseska‐Karanfilska, D., Peterlin, B.
Format: Article
Language:English
Subjects:
Adult
Alleles
Case-Control Studies
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
idiopathic male infertility
Infertility, Male - genetics
leptin
Leptin - genetics
leptin receptor
Macedonia (Republic)
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Leptin - genetics
Risk Factors
Serbia
single nucleotide polymorphisms
Sperm Count
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cited_by cdi_FETCH-LOGICAL-c3935-ec930a1adbf95cb07e453b869c54f54d5109be801b00a5586449a08a4ae6c1973
cites cdi_FETCH-LOGICAL-c3935-ec930a1adbf95cb07e453b869c54f54d5109be801b00a5586449a08a4ae6c1973
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container_issue 1
container_start_page 70
container_title Andrology (Oxford)
container_volume 5
creator Hodžić, A.
Ristanović, M.
Zorn, B.
Tulić, C.
Maver, A.
Novaković, I.
Plaseska‐Karanfilska, D.
Peterlin, B.
description Summary The aim of this study was to examine whether there is an association among genetic variability in leptin (LEP) and leptin receptor (LEPR) genes and male infertility. We performed a case–control study and were searching for an association between polymorphisms of LEP and LEPR genes and male infertility. The study group consisted of 317 patients with idiopathic infertility and a control group of 241 fertile men from Slovenia. Four single nucleotide polymorphisms (SNPs) in LEP gene and four single nucleotide polymorphisms (SNPs) in LEPR gene were chosen and genotyped. Statistically significant SNP was further validated in additional 255 infertile patients and 168 controls from Serbia and Macedonia. In the Slovenian population, we found a statistically significant difference in genotype distribution for rs10244329 polymorphism in LEP gene (recessive genotype model, p value = 0.048). The trend toward statistically significant difference in genotype distribution for rs10244329 polymorphism was confirmed in the Serbian and Macedonian populations (p value = 0.07). Our data suggest that genetic variability in the LEP gene might be associated with male infertility warranting further confirmation and mechanistic investigations.
doi_str_mv 10.1111/andr.12295
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We performed a case–control study and were searching for an association between polymorphisms of LEP and LEPR genes and male infertility. The study group consisted of 317 patients with idiopathic infertility and a control group of 241 fertile men from Slovenia. Four single nucleotide polymorphisms (SNPs) in LEP gene and four single nucleotide polymorphisms (SNPs) in LEPR gene were chosen and genotyped. Statistically significant SNP was further validated in additional 255 infertile patients and 168 controls from Serbia and Macedonia. In the Slovenian population, we found a statistically significant difference in genotype distribution for rs10244329 polymorphism in LEP gene (recessive genotype model, p value = 0.048). The trend toward statistically significant difference in genotype distribution for rs10244329 polymorphism was confirmed in the Serbian and Macedonian populations (p value = 0.07). 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source Wiley-Blackwell Read & Publish Collection
subjects Adult
Alleles
Case-Control Studies
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
idiopathic male infertility
Infertility, Male - genetics
leptin
Leptin - genetics
leptin receptor
Macedonia (Republic)
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Leptin - genetics
Risk Factors
Serbia
single nucleotide polymorphisms
Sperm Count
title Genetic variation in leptin and leptin receptor genes as a risk factor for idiopathic male infertility
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