Construction of 9H‑Pyrrolo[1,2‑a]indoles by a Copper-Catalyzed Friedel–Crafts Alkylation/Annulation Cascade Reaction

An efficient and concise Cu­(OTf)2-catalyzed Friedel–Crafts alkylation/annulation cascade reaction of substituted indoles with 1,2-dicarbonyl-3-enes has been established. This reaction uses readily available starting materials and is operationally simple, thus representing a practical method for the...

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Bibliographic Details
Published in:Journal of organic chemistry 2016-12, Vol.81 (23), p.11987-11993
Main Authors: Sun, Yongqing, Qiao, Yu, Zhao, Haiying, Li, Baoguo, Chen, Shufeng
Format: Article
Language:English
Online Access:Get full text
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Summary:An efficient and concise Cu­(OTf)2-catalyzed Friedel–Crafts alkylation/annulation cascade reaction of substituted indoles with 1,2-dicarbonyl-3-enes has been established. This reaction uses readily available starting materials and is operationally simple, thus representing a practical method for the construction of diverse 9H-pyrrolo­[1,2-a]­indoles bearing a carbonyl group.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.6b02143