Cutaneous syncytial myoepithelioma:: Clinico-pathological features and differential diagnosis

Cutaneous syncytial myoepithelioma (CSM) is a very rare tumor belonging to the spectrum of skin myoepithelial lesions. CSM usually affects the upper extremities of young to middle aged patients and is characterized by peculiar morphological and immunohistochemical features. Unlike classic myoepithel...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2016-10, Vol.212 (10), p.954-956
Main Authors: Pizzi, Marco, Facchin, Federico, Kohlscheen, Eva, Sartore, Leonardo, Salmaso, Roberto, Bassetto, Franco
Format: Article
Language:English
Subjects:
Adult
Biomarkers, Tumor - metabolism
Diagnosis, Differential
Humans
Male
Myoepithelial tumors
Myoepithelioma - diagnosis
Myoepithelioma - metabolism
Myoepithelioma - pathology
Skin Neoplasms - diagnosis
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Skin tumors
Soft tissue tumors
Syncytial myoepithelioma
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Description
Summary:Cutaneous syncytial myoepithelioma (CSM) is a very rare tumor belonging to the spectrum of skin myoepithelial lesions. CSM usually affects the upper extremities of young to middle aged patients and is characterized by peculiar morphological and immunohistochemical features. Unlike classic myoepithelioma, CSM is composed by a densely packed proliferation of spindled to histiocytoid cells, which are variably positive for EMA, S100, SMA, and frequently negative for cytokeratins and GFAP. The peculiar histopathology and the extreme rarity of such lesion (less than 40 cases reported in the literature) can make the diagnosis of CSM a true challenge. In the present case, we report the clinico-pathological features of a primary CSM occurring in a 38 year-old Caucasian man. The differential diagnoses of such lesion are also briefly discussed.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2016.07.013