A method to switch from oral dopamine agonists to rotigotine in patients with restless legs syndrome and mild augmentation

Highlights • Augmentation of RLS symptoms with oral dopamine agonists is common. • Optimal management of augmentation in such cases is controversial. • Cross-titration to rotigotine was successful in 70% of patients with mild augmentation at 5 weeks. • However, at 1 year, 50% had discontinued rotigo...

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Bibliographic Details
Published in:Sleep medicine 2016-08, Vol.24, p.18-23
Main Authors: Winkelman, John W, MD, PhD, Mackie, Susan E, Mei, Leslie A, Platt, Samuel, Schoerning, Laura
Format: Article
Language:English
Subjects:
Administration, Oral
Aged
Augmentation
Benzothiazoles - therapeutic use
Dopamine Agonists - therapeutic use
Drug Synergism
Female
Humans
Indoles - therapeutic use
Male
Neurology
Pramipexole
Restless legs syndrome
Restless Legs Syndrome - drug therapy
Ropinirole
Rotigotine
Severity of Illness Index
Sleep Medicine
Tetrahydronaphthalenes - adverse effects
Tetrahydronaphthalenes - therapeutic use
Thiophenes - adverse effects
Thiophenes - therapeutic use
Time Factors
Transdermal Patch
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Summary:Highlights • Augmentation of RLS symptoms with oral dopamine agonists is common. • Optimal management of augmentation in such cases is controversial. • Cross-titration to rotigotine was successful in 70% of patients with mild augmentation at 5 weeks. • However, at 1 year, 50% had discontinued rotigotine due to lack of continued efficacy or side effects.
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2016.05.004