From bench to operating theater: has the time come for a molecular scalpel?

The use of 5-aminolevulinic acid (5-ALA) is another promising approach, which leads to the intracellular accumulation of fluorescent porphyrins in malignant gliomas. [...]under violet-blue illumination, tumor tissue can be readily identified by the surgeon. When samples were analyzed from areas with...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2017-01, Vol.13 (2), p.121-123
Main Authors: Vartholomatos, George, Alexiou, George A, Lianos, Georgios D, Kyritsis, Athanasios P
Format: Article
Language:English
Subjects:
Accuracy
Acids
Biopsy - methods
Brain cancer
Cell cycle
Cytodiagnosis - methods
Flow cytometry
Humans
intraoperative cell cycle analyses
Intraoperative Period
Margins of Excision
Mass spectrometry
Neoplasm Grading - methods
Neoplasm Staging - methods
Neoplasms - diagnosis
Neoplasms - surgery
NMR
Nuclear magnetic resonance
Pediatrics
Scientific imaging
Surgery
surgical margins
surgical oncology
Tumors
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Summary:The use of 5-aminolevulinic acid (5-ALA) is another promising approach, which leads to the intracellular accumulation of fluorescent porphyrins in malignant gliomas. [...]under violet-blue illumination, tumor tissue can be readily identified by the surgeon. When samples were analyzed from areas with MRI contrast enhancement, there was solid tumor in 39.3% and an infiltration zone in 25% of samples(2). [...]alternative techniques that will enable the discrimination between neoplastic and normal tissue are needed. Using REIMS, Balogetal. evaluated samples ex vivo from 1624 cancerous, 1231 healthy and 78 benign and inflammatory bowel disease specimens in order to construct a database of nearly 3000 tissue-specific mass spectra(6).
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2016-0413