Effects of a multimodal rehabilitation programme on inflammation and oxidative stress in oesophageal cancer survivors: the ReStOre feasibility study

• Published in: Supportive care in cancer 2017-03, Vol.25 (3), p.749-756
• Main Authors: Guinan, Emer M, Doyle, Suzanne L, O’Neill, Linda, Dunne, Margaret R, Foley, Emma K, O’Sullivan, Jacintha, Reynolds, John V, Hussey, Juliette
• Format: Article
• Language: English
• Subjects: Activities of daily living; Analysis; Cancer research; Cancer treatment; Diet; Education; Enzyme-linked immunosorbent assay; Enzymes; Esophageal cancer; Esophageal Neoplasms - metabolism; Esophageal Neoplasms - pathology; Esophageal Neoplasms - rehabilitation; Esophageal Neoplasms - surgery; Exercise; Feasibility Studies; Female; Humans; Inflammation; Inflammation - blood; Inflammation - pathology; Interleukins; Interleukins - blood; Lactates; Male; Medicine; Medicine & Public Health; Middle Aged; Nursing; Nursing Research; Oncology; Original Article; Oxidative Stress; Pain Medicine; Physical fitness; Prospective Studies; Quality of Life; Rehabilitation; Rehabilitation Medicine; Survivor; Survivors; Tumor necrosis factor
• ISSN: 0941-4355; 1433-7339
• DOI: 10.1007/s00520-016-3455-0

Purpose Physical, nutritional and quality-of-life compromises are known sequelae of oesophageal cancer (OC) treatment. Inflammation and oxidative stress may be relevant to adverse consequences. Multimodal rehabilitation involving exercise and diet prescription may attenuate some of the negative consequences and optimise survivorship, and this was assessed in this feasibility study in OC patients at least 1 year post-oesophagectomy. Methods The 12-week programme included supervised and home-based exercise, dietetic counselling to ensure energy balance and multidisciplinary education. Baseline and post-intervention assessments examined aerobic fitness, physical activity and body composition. Serum interleukin (IL)-1β, tumour necrosis factor (TNF)-α, IL-6 and IL-8 were measured via multiplex arrays. Lactate secretion, lipid peroxidation (4-HNE) and oxidative stress (8-iso-PGF2α) were measured by enzyme-linked immunosorbent assay (ELISA). Results Twelve patients (mean (SD) age 64(1.29) years) participated. IL-8 reduced significantly from pre- to post-intervention (percentage change −11.25 % (95 % CI −20.98 to −1.51 %), p  = 0.03), and there was a non-significant trend towards lower expression patterns of other inflammatory mediators. At baseline, inflammatory status correlated inversely with sedentary behaviour (IL-6 rho = −0.74, IL-8 rho = −0.59, TNF-α rho = −0.69; p