The effect of a lipid composition and a surfactant on the characteristics of the solid lipid microspheres and nanospheres (SLM and SLN)

• Published in: European journal of pharmaceutics and biopharmaceutics 2017-01, Vol.110, p.24-30
• Main Authors: Sznitowska, Malgorzata, Wolska, Eliza, Baranska, Helena, Cal, Krzysztof, Pietkiewicz, Justyna
• Format: Article
• Language: English
• Subjects: Biomechanical Phenomena; Diglycerides - chemistry; Fatty Acids - chemistry; Hot Temperature; Lipids; Lipids - chemistry; Microparticles; Microscopy; Microspheres; Nanoparticles - chemistry; Nanospheres - chemistry; Particle Size; Polysorbates - chemistry; Pressure; Pulmonary Surfactants - chemistry; Solid lipid nanoparticles; Surface-Active Agents - chemistry; Surfactants; Triglycerides - chemistry; Ultrasound; Viscosity
• ISSN: 0939-6411; 1873-3441
• DOI: 10.1016/j.ejpb.2016.10.023

[Display omitted] Solid lipid microparticles (SLM) were produced by a two-step process that, firstly, involved the emulsification of the molten lipid phase in a heated aqueous phase and, secondly, the system cooling. Compritol 888 ATO and Precirol ATO 5, including their mixtures with Miglyol 812 or Witepsol H15 were used as lipid components (10–30% w/w). The average size of the SLM prepared with Compritol and Tween 80 as an emulsifier was 3–7μm and the influence of lipid concentration and thermal sterilization was not large. Dispersions of SLM with Precirol (10–20% w/w) gellified upon storage. SLM stabilized with another surfactant, Tego Care 450, were larger in size and measured 40μm on average. The use of the sonication step (5–15min) in hot formulations containing 5% w/w of Compritol resulted in the formation of the solid lipid nanoparticles (SLN) with average size 200–300nm. The smallest SLN size (below 100nm on average) was obtained in SLN that contained Tego Care and an antimicrobial agent Euxyl PE 9010; such combination evoked synergism between the surfactant and Euxyl components.