Co-delivery of curcumin and STAT3 siRNA using deformable cationic liposomes to treat skin cancer

Skin cancer is one of the most widely prevalent cancer types with over expression of multiple oncogenic signaling molecules including STAT3. Curcumin is a natural compound with effective anti-cancer properties. The objective of this work was to investigate the liposomal co-delivery of curcumin and S...

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Bibliographic Details
Published in:Journal of drug targeting 2017-04, Vol.25 (4), p.330-341
Main Authors: Jose, Anup, Labala, Suman, Venuganti, Venkata Vamsi Krishna
Format: Article
Language:English
Subjects:
Apoptosis - drug effects
Cationic liposome
Cations
Cell Line, Tumor
curcumin
Curcumin - administration & dosage
Curcumin - pharmacology
Curcumin - therapeutic use
Humans
Iontophoresis
Liposomes
Particle Size
RNA, Small Interfering - administration & dosage
RNA, Small Interfering - pharmacology
RNA, Small Interfering - therapeutic use
Skin Absorption
skin cancer
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
STAT3 siRNA
STAT3 Transcription Factor - genetics
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Summary:Skin cancer is one of the most widely prevalent cancer types with over expression of multiple oncogenic signaling molecules including STAT3. Curcumin is a natural compound with effective anti-cancer properties. The objective of this work was to investigate the liposomal co-delivery of curcumin and STAT3 siRNA by non-invasive topical iontophoretic application to treat skin cancer. Curcumin was encapsulated in cationic liposomes and then complexed with STAT3 siRNA. The liposomal nanocomplex was characterized for particle size, zeta-potential, drug release and stability. Human epidermoid (A431) cancer cells were used to study the cell uptake, growth inhibition and apoptosis induction of curcumin-loaded liposome-siRNA complex. Topical iontophoresis was applied to study the skin penetration of nanocomplex in excised porcine skin model. Results showed that curcumin-loaded liposome-siRNA complex was rapidly taken up by cells preferentially through clathrin-mediated endocytosis pathway. The co-delivery of curcumin and STAT3 siRNA using liposomes resulted in significantly (p 
ISSN:1061-186X
1029-2330
DOI:10.1080/1061186X.2016.1258567