Trifluoperazine: a broad spectrum bactericide especially active on staphylococci and vibrios

• Published in: International journal of antimicrobial agents 2001-10, Vol.18 (4), p.403-406
• Main Authors: Mazumder, Rupa, Ganguly, Kumkum, Dastidar, Sujata G, Chakrabarty, A.N
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimicrobial activity; Biological and medical sciences; Broad spectrum bactericide; Lethal Dose 50; Medical sciences; Mice; Microbial Sensitivity Tests; Non-antibiotic; Pharmacology. Drug treatments; Phenothiazine; Salmonella Infections, Animal - drug therapy; Salmonella Infections, Animal - microbiology; Salmonella typhimurium - drug effects; Staphylococcus - drug effects; Survival Analysis; Trifluoperazine; Trifluoperazine - pharmacology; Trifluoperazine - therapeutic use; Vibrio - drug effects
• ISSN: 0924-8579; 1872-7913
• DOI: 10.1016/S0924-8579(01)00324-7

Trifluoperazine showed some significant antimicrobial activity when tested against 293 strains from two Gram-positive and eight Gram-negative genera. Minimum inhibitory concentrations of the drug were measured using an agar dilution technique. Forty six of 55 strains of Staphylococcus aureus were inhibited by 10–50 μg/ml of trifluoperazine. This drug also inhibited strains of Shigella spp., Vibrio cholerae and V. parahaemolyticus at a concentration of 10–100 μg/ml. Other bacteria including Pseudomonas spp. were moderately sensitive to trifluoperazine. In the in vivo studies this compound offered significant protection to Swiss albino mice at a concentration of 30 μg/mouse ( P