Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum

Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats s...

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Bibliographic Details
Published in:Brain research 2002-04, Vol.933 (2), p.144-149
Main Authors: D’Este, Loredana, Scontrini, Alessandra, Casini, Arianna, Pontieri, Francesco E., Renda, Tindaro G.
Format: Article
Language:English
Subjects:
Animals
Basal Ganglia - cytology
Basal Ganglia - drug effects
Basal Ganglia - metabolism
Behavior, Animal - drug effects
Behavior, Animal - physiology
Biological and medical sciences
Brain Mapping
c-Fos oncoprotein
Caudate-putamen
Cell Count
Dopamine - metabolism
Drug addictions
Drug Tolerance - physiology
Heroin
Heroin - pharmacology
Heroin Dependence - metabolism
Heroin Dependence - pathology
Heroin Dependence - physiopathology
Immunohistochemistry
Male
Medical sciences
Motor Activity - drug effects
Motor Activity - physiology
Narcotics - pharmacology
Neostriatum - cytology
Neostriatum - drug effects
Neostriatum - metabolism
Neural Pathways - drug effects
Neural Pathways - metabolism
Neurons - cytology
Neurons - drug effects
Neurons - metabolism
Nucleus Accumbens - cytology
Nucleus Accumbens - drug effects
Nucleus Accumbens - metabolism
Nucleus accumbens shell
Proto-Oncogene Proteins c-fos - drug effects
Proto-Oncogene Proteins c-fos - metabolism
Rats
Rats, Sprague-Dawley
Reward
Sensitization
Toxicology
Up-Regulation - drug effects
Up-Regulation - physiology
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Summary:Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat’s drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(02)02312-0