The influence of phthalates and bisphenol A on the obesity development and glucose metabolism disorders

The prevalence of obesity and type 2 diabetes mellitus epidemics presents a great health problem worldwide. Beside the changes in diet and decreased physical activity, there is growing interest in endocrine disrupting chemicals that may have effects on these conditions. Among them, the role of certa...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine 2017-03, Vol.55 (3), p.666-681
Main Authors: Stojanoska, Milica Medic, Milosevic, Natasa, Milic, Natasa, Abenavoli, Ludovico
Format: Article
Language:English
Subjects:
Benzhydryl Compounds - toxicity
Bisphenol A
Diabetes
Diabetes mellitus
Diethyl phthalate
Diisononyl phthalate
Endocrine disruptors
Endocrinology
Environmental Exposure - adverse effects
Epidemics
Glucose metabolism
Glucose Metabolism Disorders - chemically induced
Homeostasis
Humanities and Social Sciences
Humans
Internal Medicine
Medicine
Medicine & Public Health
multidisciplinary
Obesity
Obesity - chemically induced
Phenols - toxicity
Phthalate esters
Phthalic Acids - toxicity
Physical activity
Review
Science
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The prevalence of obesity and type 2 diabetes mellitus epidemics presents a great health problem worldwide. Beside the changes in diet and decreased physical activity, there is growing interest in endocrine disrupting chemicals that may have effects on these conditions. Among them, the role of certain phthalates and bisphenol A is confirmed. We have summarized the existing literature on this issue including cross-sectional, follow up epidemiological studies and in vivo and in vitro studies. Most data support the effects of bisphenol A and some phthalates, such as di-2-ethyl-hexyl phthalate, diethyl phthalate, dibuthyl phthalate, dimethyl phthalate, dibenzyl phthalate, diisononyl phthalate and others on the development obesity and type 2 diabetes mellitus. These endocrine disrupting chemicals interfere with different cell signaling pathways involved in weight and glucose homeostasis. Since the data are rather inconsistent, there is a need for new, well-designed prospective studies.
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-016-1158-4