Prodrug approach: An overview of recent cases

In this review we highlight the most modern trends in the prodrug strategy. In drug research and development, the prodrug concept has found a number of useful applications. Selected examples of this approach are provided in this paper and they are classified according to the aim of their design. [Di...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2017-02, Vol.127, p.810-827
Main Authors: Abet, Valentina, Filace, Fabiana, Recio, Javier, Alvarez-Builla, Julio, Burgos, Carolina
Format: Article
Language:English
Subjects:
Absorption, Physicochemical
Animals
Bioprecursors
Carrier-linked prodrug
Cell Membrane Permeability
Drug Discovery - methods
Humans
Prodrug
Prodrugs - adverse effects
Prodrugs - chemistry
Prodrugs - metabolism
Solubility
Water - chemistry
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Summary:In this review we highlight the most modern trends in the prodrug strategy. In drug research and development, the prodrug concept has found a number of useful applications. Selected examples of this approach are provided in this paper and they are classified according to the aim of their design. [Display omitted] •A prodrug is an inactive compound that undergoes biotransformation to supply a drug.•Types of prodrugs:ˆCarrier-linked prodrugsˆBioprecursors•A prodrug is an inexpensive and patentable modification of a bioactive entity.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2016.10.061