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Prodrug approach: An overview of recent cases
In this review we highlight the most modern trends in the prodrug strategy. In drug research and development, the prodrug concept has found a number of useful applications. Selected examples of this approach are provided in this paper and they are classified according to the aim of their design. [Di...
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| Published in: | European journal of medicinal chemistry 2017-02, Vol.127, p.810-827 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c408t-bbdaa6be096785f7620baa9c8e12b18bd325d2c473167215b1a58b6540ddf1c93 |
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| cites | cdi_FETCH-LOGICAL-c408t-bbdaa6be096785f7620baa9c8e12b18bd325d2c473167215b1a58b6540ddf1c93 |
| container_end_page | 827 |
| container_issue | |
| container_start_page | 810 |
| container_title | European journal of medicinal chemistry |
| container_volume | 127 |
| creator | Abet, Valentina Filace, Fabiana Recio, Javier Alvarez-Builla, Julio Burgos, Carolina |
| description | In this review we highlight the most modern trends in the prodrug strategy. In drug research and development, the prodrug concept has found a number of useful applications. Selected examples of this approach are provided in this paper and they are classified according to the aim of their design.
[Display omitted]
•A prodrug is an inactive compound that undergoes biotransformation to supply a drug.•Types of prodrugs:ˆCarrier-linked prodrugsˆBioprecursors•A prodrug is an inexpensive and patentable modification of a bioactive entity. |
| doi_str_mv | 10.1016/j.ejmech.2016.10.061 |
| format | article |
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•A prodrug is an inactive compound that undergoes biotransformation to supply a drug.•Types of prodrugs:ˆCarrier-linked prodrugsˆBioprecursors•A prodrug is an inexpensive and patentable modification of a bioactive entity.</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2016.10.061</identifier><identifier>PMID: 27823878</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Absorption, Physicochemical ; Animals ; Bioprecursors ; Carrier-linked prodrug ; Cell Membrane Permeability ; Drug Discovery - methods ; Humans ; Prodrug ; Prodrugs - adverse effects ; Prodrugs - chemistry ; Prodrugs - metabolism ; Solubility ; Water - chemistry</subject><ispartof>European journal of medicinal chemistry, 2017-02, Vol.127, p.810-827</ispartof><rights>2016 Elsevier Masson SAS</rights><rights>Copyright © 2016 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-bbdaa6be096785f7620baa9c8e12b18bd325d2c473167215b1a58b6540ddf1c93</citedby><cites>FETCH-LOGICAL-c408t-bbdaa6be096785f7620baa9c8e12b18bd325d2c473167215b1a58b6540ddf1c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27900,27901</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27823878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abet, Valentina</creatorcontrib><creatorcontrib>Filace, Fabiana</creatorcontrib><creatorcontrib>Recio, Javier</creatorcontrib><creatorcontrib>Alvarez-Builla, Julio</creatorcontrib><creatorcontrib>Burgos, Carolina</creatorcontrib><title>Prodrug approach: An overview of recent cases</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>In this review we highlight the most modern trends in the prodrug strategy. In drug research and development, the prodrug concept has found a number of useful applications. Selected examples of this approach are provided in this paper and they are classified according to the aim of their design.
[Display omitted]
•A prodrug is an inactive compound that undergoes biotransformation to supply a drug.•Types of prodrugs:ˆCarrier-linked prodrugsˆBioprecursors•A prodrug is an inexpensive and patentable modification of a bioactive entity.</description><subject>Absorption, Physicochemical</subject><subject>Animals</subject><subject>Bioprecursors</subject><subject>Carrier-linked prodrug</subject><subject>Cell Membrane Permeability</subject><subject>Drug Discovery - methods</subject><subject>Humans</subject><subject>Prodrug</subject><subject>Prodrugs - adverse effects</subject><subject>Prodrugs - chemistry</subject><subject>Prodrugs - metabolism</subject><subject>Solubility</subject><subject>Water - chemistry</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqXwBwhlySbBduJHWCBVFS-pEixgbfkxoYmapNhpEX-PqxSWrEZzdWfuzEHokuCMYMJvmgyaFuwqo7GLUoY5OUJTIrhMc8qKYzTFlOYpo3kxQWchNBhjxjE-RRMqJM2lkFOUvvre-e1Hojcb32u7uk3mXdLvwO9q-Er6KvFgoRsSqwOEc3RS6XWAi0OdofeH-7fFU7p8eXxezJepLbAcUmOc1twALrmQrBKcYqN1aSUQaog0Lt7nqC1ETrighBmimTScFdi5itgyn6HrcW-86XMLYVBtHSys17qDfhsUkbmgUvKSRWsxWq3vQ_BQqY2vW-2_FcFqD0o1agSl9qD2agQVx64OCVvTgvsb-iUTDXejAeKfkYVXwdbQWXB1JDIo19f_J_wAKNN5wQ</recordid><startdate>20170215</startdate><enddate>20170215</enddate><creator>Abet, Valentina</creator><creator>Filace, Fabiana</creator><creator>Recio, Javier</creator><creator>Alvarez-Builla, Julio</creator><creator>Burgos, Carolina</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170215</creationdate><title>Prodrug approach: An overview of recent cases</title><author>Abet, Valentina ; Filace, Fabiana ; Recio, Javier ; Alvarez-Builla, Julio ; Burgos, Carolina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-bbdaa6be096785f7620baa9c8e12b18bd325d2c473167215b1a58b6540ddf1c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Absorption, Physicochemical</topic><topic>Animals</topic><topic>Bioprecursors</topic><topic>Carrier-linked prodrug</topic><topic>Cell Membrane Permeability</topic><topic>Drug Discovery - methods</topic><topic>Humans</topic><topic>Prodrug</topic><topic>Prodrugs - adverse effects</topic><topic>Prodrugs - chemistry</topic><topic>Prodrugs - metabolism</topic><topic>Solubility</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abet, Valentina</creatorcontrib><creatorcontrib>Filace, Fabiana</creatorcontrib><creatorcontrib>Recio, Javier</creatorcontrib><creatorcontrib>Alvarez-Builla, Julio</creatorcontrib><creatorcontrib>Burgos, Carolina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abet, Valentina</au><au>Filace, Fabiana</au><au>Recio, Javier</au><au>Alvarez-Builla, Julio</au><au>Burgos, Carolina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prodrug approach: An overview of recent cases</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2017-02-15</date><risdate>2017</risdate><volume>127</volume><spage>810</spage><epage>827</epage><pages>810-827</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><abstract>In this review we highlight the most modern trends in the prodrug strategy. In drug research and development, the prodrug concept has found a number of useful applications. Selected examples of this approach are provided in this paper and they are classified according to the aim of their design.
[Display omitted]
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| fulltext | fulltext |
| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 2017-02, Vol.127, p.810-827 |
| issn | 0223-5234 1768-3254 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1837288695 |
| source | ScienceDirect Freedom Collection |
| subjects | Absorption, Physicochemical Animals Bioprecursors Carrier-linked prodrug Cell Membrane Permeability Drug Discovery - methods Humans Prodrug Prodrugs - adverse effects Prodrugs - chemistry Prodrugs - metabolism Solubility Water - chemistry |
| title | Prodrug approach: An overview of recent cases |
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