The Esophagiome: concept, status, and future perspectives

The term “Esophagiome” is meant to imply a holistic, multiscale treatment of esophageal function from cellular and muscle physiology to the mechanical responses that transport and mix fluid contents. The development and application of multiscale mathematical models of esophageal function are central...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2016-09, Vol.1380 (1), p.6-18
Main Authors: Gregersen, Hans, Liao, Donghua, Brasseur, James G.
Format: Article
Language:English
Subjects:
Biomechanical Phenomena - physiology
biomechanics
Esophagiome
esophagogastric junction
Esophagogastric Junction - physiology
Esophagus
Esophagus - physiology
Forecasting
gastrointestinal
GIOME
Humans
Manometry - methods
Manometry - trends
modeling
Muscle Contraction - physiology
neurophysiology
Patient-Specific Modeling - trends
peristalsis
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Summary:The term “Esophagiome” is meant to imply a holistic, multiscale treatment of esophageal function from cellular and muscle physiology to the mechanical responses that transport and mix fluid contents. The development and application of multiscale mathematical models of esophageal function are central to the Esophagiome concept. These model elements underlie the development of a “virtual esophagus” modeling framework to characterize and analyze function and disease by quantitatively contrasting normal and pathophysiological function. Functional models incorporate anatomical details with sensory–motor properties and functional responses, especially related to biomechanical functions, such as bolus transport and gastrointestinal fluid mixing. This brief review provides insight into Esophagiome research. Future advanced models can provide predictive evaluations of the therapeutic consequences of surgical and endoscopic treatments and will aim to facilitate clinical diagnostics and treatment.
ISSN:0077-8923
1749-6632
DOI:10.1111/nyas.13200