Analytical characteristics and application of novel chitosan coated magnetic nanoparticles as an efficient drug delivery system for ciprofloxacin. Enhanced drug release kinetics by low-frequency ultrasounds

[Display omitted] •Synthesize of pH-responsive chitosan coated magnetic nanoparticles for controlled ciprofloxacin release.•Study of effect of the drug:carrier ratio and pH on loading efficiency of ciprofloxacin.•Quantitative loading of drug over a time period of 48h at pH 4.8.•Quantitative in vitro...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2016-09, Vol.129, p.450-457
Main Authors: Kariminia, Samira, Shamsipur, Ali, Shamsipur, Mojtaba
Format: Article
Language:English
Subjects:
Administration, Oral
Analytical characteristics of drug delivery system
Chitosan
Chitosan - chemistry
Ciprofloxacin
Ciprofloxacin - chemistry
Drug Carriers - chemistry
Drug Delivery Systems - methods
Drug Liberation
Iron oxide nanoparticles
Kinetics
Magnetite Nanoparticles - chemistry
Particle Size
Spectroscopy, Fourier Transform Infrared - methods
Ultrasound
X-Ray Diffraction - methods
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Summary:[Display omitted] •Synthesize of pH-responsive chitosan coated magnetic nanoparticles for controlled ciprofloxacin release.•Study of effect of the drug:carrier ratio and pH on loading efficiency of ciprofloxacin.•Quantitative loading of drug over a time period of 48h at pH 4.8.•Quantitative in vitro release of drug over a sustained period of 5days at pH 7.4.•The ultrasonically triggered fast and quantitative release of drug at pH 7.4 in
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2016.07.016