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Analytical characteristics and application of novel chitosan coated magnetic nanoparticles as an efficient drug delivery system for ciprofloxacin. Enhanced drug release kinetics by low-frequency ultrasounds
[Display omitted] •Synthesize of pH-responsive chitosan coated magnetic nanoparticles for controlled ciprofloxacin release.•Study of effect of the drug:carrier ratio and pH on loading efficiency of ciprofloxacin.•Quantitative loading of drug over a time period of 48h at pH 4.8.•Quantitative in vitro...
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| Published in: | Journal of pharmaceutical and biomedical analysis 2016-09, Vol.129, p.450-457 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Kariminia, Samira Shamsipur, Ali Shamsipur, Mojtaba |
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•Synthesize of pH-responsive chitosan coated magnetic nanoparticles for controlled ciprofloxacin release.•Study of effect of the drug:carrier ratio and pH on loading efficiency of ciprofloxacin.•Quantitative loading of drug over a time period of 48h at pH 4.8.•Quantitative in vitro release of drug over a sustained period of 5days at pH 7.4.•The ultrasonically triggered fast and quantitative release of drug at pH 7.4 in |
| doi_str_mv | 10.1016/j.jpba.2016.07.016 |
| format | article |
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•Synthesize of pH-responsive chitosan coated magnetic nanoparticles for controlled ciprofloxacin release.•Study of effect of the drug:carrier ratio and pH on loading efficiency of ciprofloxacin.•Quantitative loading of drug over a time period of 48h at pH 4.8.•Quantitative in vitro release of drug over a sustained period of 5days at pH 7.4.•The ultrasonically triggered fast and quantitative release of drug at pH 7.4 in <60min.
A pH-responsive drug carrier based on chitosan coated iron oxide nanoparticles (CS-Fe3O4) for prolonged antibiotic release in a controlled manner is reported. As an antibiotic drug model, ciprofloxacin was loaded onto the nanocarrier via H-bonding interactions. The nanoparticles were characterized using scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, photon correlation spectroscopy and Fourier transform infrared spectroscopy. The particle size of CS-Fe3O4 nanoparticles were found to lie in the range of 30–80nm. The analytical characteristics of the designed system were thoroughly investigated. The in vitro drug loading at pH 4.8 and release kinetics at pH 7.4 studies revealed that the drug delivery system can take 99% of ciprofloxacin load and quantitatively release the drug over a sustained period of 5 days. The release kinetics study indicated that the system follows a zero order kinetics via a diffusion-controlled mechanism. These results indicated that CS-Fe3O4 nanoparticles have the potential for use as controlled antibiotic delivery systems through oral administration by avoiding the drug release in the highly acidic gastric fluid region of the stomach. Furthermore, the ability of low-frequency ultrasound in fast release of the encapsulated drug in less than 60min from the CS-Fe3O4 nanoparticles in a controlled manner was confirmed.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2016.07.016</identifier><identifier>PMID: 27497305</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Administration, Oral ; Analytical characteristics of drug delivery system ; Chitosan ; Chitosan - chemistry ; Ciprofloxacin ; Ciprofloxacin - chemistry ; Drug Carriers - chemistry ; Drug Delivery Systems - methods ; Drug Liberation ; Iron oxide nanoparticles ; Kinetics ; Magnetite Nanoparticles - chemistry ; Particle Size ; Spectroscopy, Fourier Transform Infrared - methods ; Ultrasound ; X-Ray Diffraction - methods</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2016-09, Vol.129, p.450-457</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-10aec3184e23a37dd53d702beddc7f2f2f0a8555e81a37edd8953084e434d0d23</citedby><cites>FETCH-LOGICAL-c389t-10aec3184e23a37dd53d702beddc7f2f2f0a8555e81a37edd8953084e434d0d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27497305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kariminia, Samira</creatorcontrib><creatorcontrib>Shamsipur, Ali</creatorcontrib><creatorcontrib>Shamsipur, Mojtaba</creatorcontrib><title>Analytical characteristics and application of novel chitosan coated magnetic nanoparticles as an efficient drug delivery system for ciprofloxacin. Enhanced drug release kinetics by low-frequency ultrasounds</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>[Display omitted]
•Synthesize of pH-responsive chitosan coated magnetic nanoparticles for controlled ciprofloxacin release.•Study of effect of the drug:carrier ratio and pH on loading efficiency of ciprofloxacin.•Quantitative loading of drug over a time period of 48h at pH 4.8.•Quantitative in vitro release of drug over a sustained period of 5days at pH 7.4.•The ultrasonically triggered fast and quantitative release of drug at pH 7.4 in <60min.
A pH-responsive drug carrier based on chitosan coated iron oxide nanoparticles (CS-Fe3O4) for prolonged antibiotic release in a controlled manner is reported. As an antibiotic drug model, ciprofloxacin was loaded onto the nanocarrier via H-bonding interactions. The nanoparticles were characterized using scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, photon correlation spectroscopy and Fourier transform infrared spectroscopy. The particle size of CS-Fe3O4 nanoparticles were found to lie in the range of 30–80nm. The analytical characteristics of the designed system were thoroughly investigated. The in vitro drug loading at pH 4.8 and release kinetics at pH 7.4 studies revealed that the drug delivery system can take 99% of ciprofloxacin load and quantitatively release the drug over a sustained period of 5 days. The release kinetics study indicated that the system follows a zero order kinetics via a diffusion-controlled mechanism. These results indicated that CS-Fe3O4 nanoparticles have the potential for use as controlled antibiotic delivery systems through oral administration by avoiding the drug release in the highly acidic gastric fluid region of the stomach. Furthermore, the ability of low-frequency ultrasound in fast release of the encapsulated drug in less than 60min from the CS-Fe3O4 nanoparticles in a controlled manner was confirmed.</description><subject>Administration, Oral</subject><subject>Analytical characteristics of drug delivery system</subject><subject>Chitosan</subject><subject>Chitosan - chemistry</subject><subject>Ciprofloxacin</subject><subject>Ciprofloxacin - chemistry</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems - methods</subject><subject>Drug Liberation</subject><subject>Iron oxide nanoparticles</subject><subject>Kinetics</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Particle Size</subject><subject>Spectroscopy, Fourier Transform Infrared - methods</subject><subject>Ultrasound</subject><subject>X-Ray Diffraction - methods</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNUcFu1DAQjRCIbgs_wAH5yCXBjpO1I3GpqkKRKnEBiZs1a09aL1472M5CfpJvwukWjgj58EYz7z2P5lXVK0YbRtn27b7ZTzto2lI3VDQFnlQbJgWv22339Wm1oYKzWlDZn1XnKe0ppT0buufVWSu6QXDab6pflx7ckq0GR_Q9RNAZo02lkQh4Q2CaXBlmGzwJI_HhiCvR5pDAEx0goyEHuPNYJMSDDxPEUjos-tWC4DhabdFnYuJ8Rww6e8S4kLSkjAcyhki0nWIYXfgJ2vqGXPt78Lr4PggiOoSE5Jt9-COR3UJc-FGPEb_P6PVCZpcjpDB7k15Uz0ZwCV8-4kX15f3156ub-vbTh49Xl7e15nLINaOAmjPZYcuBC2N6bgRtd2iMFmNbHgXZ9z1KVsalK4ee00LveGeoaflF9ebkWxYvW6SsDjZpdA48hjkpJrloBy5F9x9U1vPtICkv1PZE1TGkFHFUU7QHiItiVK2Rq71aI1dr5IoKVaCIXj_6z7sDmr-SPxkXwrsTActBjhajSmse5cA2os7KBPsv_98B38Ob</recordid><startdate>20160910</startdate><enddate>20160910</enddate><creator>Kariminia, Samira</creator><creator>Shamsipur, Ali</creator><creator>Shamsipur, Mojtaba</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20160910</creationdate><title>Analytical characteristics and application of novel chitosan coated magnetic nanoparticles as an efficient drug delivery system for ciprofloxacin. Enhanced drug release kinetics by low-frequency ultrasounds</title><author>Kariminia, Samira ; Shamsipur, Ali ; Shamsipur, Mojtaba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-10aec3184e23a37dd53d702beddc7f2f2f0a8555e81a37edd8953084e434d0d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Oral</topic><topic>Analytical characteristics of drug delivery system</topic><topic>Chitosan</topic><topic>Chitosan - chemistry</topic><topic>Ciprofloxacin</topic><topic>Ciprofloxacin - chemistry</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Delivery Systems - methods</topic><topic>Drug Liberation</topic><topic>Iron oxide nanoparticles</topic><topic>Kinetics</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Particle Size</topic><topic>Spectroscopy, Fourier Transform Infrared - methods</topic><topic>Ultrasound</topic><topic>X-Ray Diffraction - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kariminia, Samira</creatorcontrib><creatorcontrib>Shamsipur, Ali</creatorcontrib><creatorcontrib>Shamsipur, Mojtaba</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kariminia, Samira</au><au>Shamsipur, Ali</au><au>Shamsipur, Mojtaba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analytical characteristics and application of novel chitosan coated magnetic nanoparticles as an efficient drug delivery system for ciprofloxacin. Enhanced drug release kinetics by low-frequency ultrasounds</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2016-09-10</date><risdate>2016</risdate><volume>129</volume><spage>450</spage><epage>457</epage><pages>450-457</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><abstract>[Display omitted]
•Synthesize of pH-responsive chitosan coated magnetic nanoparticles for controlled ciprofloxacin release.•Study of effect of the drug:carrier ratio and pH on loading efficiency of ciprofloxacin.•Quantitative loading of drug over a time period of 48h at pH 4.8.•Quantitative in vitro release of drug over a sustained period of 5days at pH 7.4.•The ultrasonically triggered fast and quantitative release of drug at pH 7.4 in <60min.
A pH-responsive drug carrier based on chitosan coated iron oxide nanoparticles (CS-Fe3O4) for prolonged antibiotic release in a controlled manner is reported. As an antibiotic drug model, ciprofloxacin was loaded onto the nanocarrier via H-bonding interactions. The nanoparticles were characterized using scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, photon correlation spectroscopy and Fourier transform infrared spectroscopy. The particle size of CS-Fe3O4 nanoparticles were found to lie in the range of 30–80nm. The analytical characteristics of the designed system were thoroughly investigated. The in vitro drug loading at pH 4.8 and release kinetics at pH 7.4 studies revealed that the drug delivery system can take 99% of ciprofloxacin load and quantitatively release the drug over a sustained period of 5 days. The release kinetics study indicated that the system follows a zero order kinetics via a diffusion-controlled mechanism. These results indicated that CS-Fe3O4 nanoparticles have the potential for use as controlled antibiotic delivery systems through oral administration by avoiding the drug release in the highly acidic gastric fluid region of the stomach. Furthermore, the ability of low-frequency ultrasound in fast release of the encapsulated drug in less than 60min from the CS-Fe3O4 nanoparticles in a controlled manner was confirmed.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>27497305</pmid><doi>10.1016/j.jpba.2016.07.016</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical and biomedical analysis, 2016-09, Vol.129, p.450-457 |
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| subjects | Administration, Oral Analytical characteristics of drug delivery system Chitosan Chitosan - chemistry Ciprofloxacin Ciprofloxacin - chemistry Drug Carriers - chemistry Drug Delivery Systems - methods Drug Liberation Iron oxide nanoparticles Kinetics Magnetite Nanoparticles - chemistry Particle Size Spectroscopy, Fourier Transform Infrared - methods Ultrasound X-Ray Diffraction - methods |
| title | Analytical characteristics and application of novel chitosan coated magnetic nanoparticles as an efficient drug delivery system for ciprofloxacin. Enhanced drug release kinetics by low-frequency ultrasounds |
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