Signal intensity change on unenhanced T1-weighted images in dentate nucleus following gadobenate dimeglumine in patients with and without previous multiple administrations of gadodiamide

Objectives To evaluate the impact of previous administration of gadodiamide and neural tissue gadolinium deposition in patients who received gadobenate dimeglumine. Methods Our population included 62 patients who underwent at least three administrations of gadobenate dimeglumine, plus an additional...

Full description

Saved in:
Bibliographic Details
Published in:European radiology 2016-11, Vol.26 (11), p.4080-4088
Main Authors: Ramalho, Joana, Semelka, Richard C, AlObaidy, Mamdoh, Ramalho, Miguel, Nunes, Renato H, Castillo, Mauricio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cerebellar Nuclei - metabolism
Cerebellum - metabolism
Contrast agents
Contrast Media
Contrast Media - administration & dosage
Contrast Media - pharmacology
Diagnostic Radiology
Drug dosages
Female
Gadolinium - metabolism
Gadolinium - pharmacology
Gadolinium DTPA - administration & dosage
Gadolinium DTPA - pharmacology
Humans
Imaging
Internal Medicine
Interventional Radiology
Longitudinal Studies
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Meglumine - administration & dosage
Meglumine - analogs & derivatives
Meglumine - pharmacology
Middle Aged
Neuroradiology
Organometallic Compounds - administration & dosage
Organometallic Compounds - pharmacology
Radiology
Ultrasound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To evaluate the impact of previous administration of gadodiamide and neural tissue gadolinium deposition in patients who received gadobenate dimeglumine. Methods Our population included 62 patients who underwent at least three administrations of gadobenate dimeglumine, plus an additional contrast-enhanced last MRI for reference, divided into two groups: group 1, patients who in addition to gadobenate dimeglumine administrations had prior exposure to multiple doses of gadodiamide; group 2, patients without previous exposure to other gadolinium-based contrast agent (GBCAs). Quantitative analysis was performed on the first and last gadobenate dimeglumine MRIs in both groups. Dentate nucleus-to-middle cerebellar peduncle signal intensity ratios (DN/MCP) and relative change (RC) in signal over time were calculated and compared between groups using generalized additive model. Results Group 1 showed significant increase in baseline and follow-up DN/MCP compared to group 2 ( p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-016-4269-7