Side-stream tobacco smoke-induced airway hyperresponsiveness in early postnatal period is involved nerve growth factor

Highlights • Exposure to cigarette smoke during early postnatal period significantly altered pulmonary function and airway innervation. • Cigarette smoke exposure during early postnatal period increased nerve growth factor and its receptor in lung in the lung. • Pretreatment with NGF antibody signif...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2016-03, Vol.223, p.1-8
Main Authors: Wu, Z-X, Hunter, D.D, Batchelor, T.P, Dey, R.D
Format: Article
Language:English
Subjects:
Airway innervation
Animals
Animals, Newborn
Asthma
Medical Education
Mice
Mice, Inbred ICR
Nerve Growth Factor - immunology
Nerve Growth Factor - metabolism
Nerve Growth Factor - pharmacology
Neurokinin receptor
Pulmonary/Respiratory
Receptors, Nerve Growth Factor - metabolism
Receptors, Neurokinin-1 - metabolism
Respiratory Hypersensitivity - chemically induced
Respiratory Hypersensitivity - prevention & control
Respiratory System - innervation
Substance P
Substance P - metabolism
Tobacco Smoke Pollution - adverse effects
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Summary:Highlights • Exposure to cigarette smoke during early postnatal period significantly altered pulmonary function and airway innervation. • Cigarette smoke exposure during early postnatal period increased nerve growth factor and its receptor in lung in the lung. • Pretreatment with NGF antibody significantly diminished cigarette smoke-induced pulmonary function.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2015.11.009