Evaluation of rheumatoid factor and anti-citrullinated peptide antibodies in relation to rheumatological manifestations in patients with leprosy from Southern Brazil

Background Leprosy patients may present several osteoarticular complaints, which require further evaluation of inflammatory diseases, such as rheumatoid arthritis (RA). Therefore, an adequate clinical assessment in addition to testing for rheumatoid factors (RF) and anticyclic citrullinated peptide...

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Bibliographic Details
Published in:International journal of rheumatic diseases 2016-10, Vol.19 (10), p.1024-1031
Main Authors: Dionello, Carla Fontoura, Rosa Utiyama, Shirley Ramos, Radominski, Sebastião Cézar, Stahlke, Ewalda, Stinghen, Servio Tulio, de Messias-Reason, Iara Jose
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
anti-CCP antibodies
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - diagnosis
Arthritis, Rheumatoid - ethnology
Arthritis, Rheumatoid - immunology
Biomarkers - blood
Brazil - epidemiology
Case-Control Studies
Female
Humans
Immunoglobulin M - blood
leprosy
Leprosy - blood
Leprosy - diagnosis
Leprosy - ethnology
Leprosy - immunology
Logistic Models
Male
Middle Aged
Odds Ratio
Peptides, Cyclic - immunology
Predictive Value of Tests
rheumatoid arthritis
rheumatoid factor
Rheumatoid Factor - blood
rheumatological manifestations
Risk Factors
Young Adult
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Summary:Background Leprosy patients may present several osteoarticular complaints, which require further evaluation of inflammatory diseases, such as rheumatoid arthritis (RA). Therefore, an adequate clinical assessment in addition to testing for rheumatoid factors (RF) and anticyclic citrullinated peptide antibodies (anti‐CCP), can be useful in order to establish the correct diagnosis. Method In this study, the relation of RF and anti‐CCP with rheumatological manifestations was evaluated in 97 leprosy patients from Southern Brazil. The results were compared to RA patients and healthy controls from the same geographical area and ethnic background. Results Neuropathy was observed in 71.1% and arthritis in 35.1% of the leprosy patients. A high frequency of RF positivity was observed among the leprosy patients (41.2%, 40/97), with RF immunoglobulin A (IgA) significantly associated with arthritis (OR = 7.9, 95% CI = 1.5–40.6 P = 0.008). Anti‐CCP was observed in 9.3% (9/97) of the patients, with anti‐CCP2 being the most frequent subtype. Only 4.1% (4/97) of the patients were RF and anti‐CCP concomitantly positive. RF IgM showed a significant association with leprosy when compared to healthy controls (P 
ISSN:1756-1841
1756-185X
DOI:10.1111/1756-185X.12668