Clinical significance of pelvic lymph node status in prostate cancer: review of 1690 cases

To assess whether any relationship exists between the number of histologically examined lymph nodes and the detection of metastases in pelvic lymph node dissection (PLND) specimens taken from patients with radical prostatectomy (RP) for prostatic adenocarcinoma. 1690 cases of RP with PNLD were inclu...

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Bibliographic Details
Published in:Internal and emergency medicine 2016-04, Vol.11 (3), p.399-404
Main Authors: Maccio, Livia, Barresi, Valeria, Domati, Federica, Martorana, Eugenio, Cesinaro, Anna Maria, Migaldi, Mario, Iachetta, Francesco, Ieni, Antonio, Bonetti, Luca Reggiani
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biopsy, Needle
Cohort Studies
Databases, Factual
Disease-Free Survival
Humans
Im - Original
Immunohistochemistry
Internal Medicine
Kaplan-Meier Estimate
Lymph Node Excision - methods
Lymph Nodes - pathology
Lymph Nodes - surgery
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Invasiveness - pathology
Neoplasm Staging
Pelvis
Prognosis
Proportional Hazards Models
Prostate-Specific Antigen - blood
Prostatectomy - methods
Prostatic Neoplasms - mortality
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Retrospective Studies
ROC Curve
Survival Rate
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Summary:To assess whether any relationship exists between the number of histologically examined lymph nodes and the detection of metastases in pelvic lymph node dissection (PLND) specimens taken from patients with radical prostatectomy (RP) for prostatic adenocarcinoma. 1690 cases of RP with PNLD were included in the study; 54 % of the patients were submitted to extended PLND (ePLND). Kaplan–Meier curves confirm the negative prognostic significance of nodal metastases on the overall patients’ survival ( P  
ISSN:1828-0447
1970-9366
DOI:10.1007/s11739-015-1375-5