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Myeloperoxidase Antineutrophil Cytoplasmic Antibody (MPO-ANCA) Associated Crescentic and Necrotizing Glomerulonephritis (GN) with Membranoproliferative GN Features

A 77-year-old man presented with a fever, non-productive cough, and edema formation. A laboratory analysis showed an elevated creatinine level (2.5 mg/dL), a high titer of myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA) (99 U/mL), positive reaction for antinuclear antibody (×320),...

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Published in:	Internal Medicine 2016/08/01, Vol.55(15), pp.2043-2048
Main Authors:	Koda, Ryo, Nagahori, Katsuhiro, Kitazawa, Atsushi, Imanishi, Yuji, Yoshino, Atsunori, Kawamoto, Shinya, Ueda, Yoshihiko, Takeda, Tetsuro
Format:	Article
Language:	English
Subjects:	Adrenal Cortex Hormones - therapeutic use Aged Antibodies, Antineutrophil Cytoplasmic - analysis antineutrophil cytoplasmic antibody (ANCA) antinuclear antibody (ANA) crescentic glomerulonephritis Glomerulonephritis - drug therapy Glomerulonephritis - immunology Glomerulonephritis - pathology Glomerulonephritis, Membranoproliferative - drug therapy Glomerulonephritis, Membranoproliferative - immunology Glomerulonephritis, Membranoproliferative - pathology Humans Immunosuppressive Agents - therapeutic use Male membranoproliferative glomerulonephritis myeloperoxidase (MPO)
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creator	Koda, Ryo Nagahori, Katsuhiro Kitazawa, Atsushi Imanishi, Yuji Yoshino, Atsunori Kawamoto, Shinya Ueda, Yoshihiko Takeda, Tetsuro
description	A 77-year-old man presented with a fever, non-productive cough, and edema formation. A laboratory analysis showed an elevated creatinine level (2.5 mg/dL), a high titer of myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA) (99 U/mL), positive reaction for antinuclear antibody (×320), hematuria, and massive proteinuria (3.33 g/day). A renal biopsy revealed crescentic and necrotizing glomerulonephritis (GN) with membranoproliferative GN features [double contour appearance of the glomerular basement membrane, granular deposition of immunoglobulin (Ig) G, IgM, and C3 along the capillary wall, subendothelial and subepithelial deposits with mesangial interposition]. A potential relationship between MPO-ANCA associated GN and membranoproliferative GN is discussed.
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A potential relationship between MPO-ANCA associated GN and membranoproliferative GN is discussed.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.55.6426</identifier><identifier>PMID: 27477412</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Adrenal Cortex Hormones - therapeutic use ; Aged ; Antibodies, Antineutrophil Cytoplasmic - analysis ; antineutrophil cytoplasmic antibody (ANCA) ; antinuclear antibody (ANA) ; crescentic glomerulonephritis ; Glomerulonephritis - drug therapy ; Glomerulonephritis - immunology ; Glomerulonephritis - pathology ; Glomerulonephritis, Membranoproliferative - drug therapy ; Glomerulonephritis, Membranoproliferative - immunology ; Glomerulonephritis, Membranoproliferative - pathology ; Humans ; Immunosuppressive Agents - therapeutic use ; Male ; membranoproliferative glomerulonephritis ; myeloperoxidase (MPO)</subject><ispartof>Internal Medicine, 2016/08/01, Vol.55(15), pp.2043-2048</ispartof><rights>2016 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c505t-a3646ecd211f71ebdf3d726ad8a771c28454697f576c26ec2b2ca803f163c6403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27477412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koda, Ryo</creatorcontrib><creatorcontrib>Nagahori, Katsuhiro</creatorcontrib><creatorcontrib>Kitazawa, Atsushi</creatorcontrib><creatorcontrib>Imanishi, Yuji</creatorcontrib><creatorcontrib>Yoshino, Atsunori</creatorcontrib><creatorcontrib>Kawamoto, Shinya</creatorcontrib><creatorcontrib>Ueda, Yoshihiko</creatorcontrib><creatorcontrib>Takeda, Tetsuro</creatorcontrib><title>Myeloperoxidase Antineutrophil Cytoplasmic Antibody (MPO-ANCA) Associated Crescentic and Necrotizing Glomerulonephritis (GN) with Membranoproliferative GN Features</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 77-year-old man presented with a fever, non-productive cough, and edema formation. A laboratory analysis showed an elevated creatinine level (2.5 mg/dL), a high titer of myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA) (99 U/mL), positive reaction for antinuclear antibody (×320), hematuria, and massive proteinuria (3.33 g/day). A renal biopsy revealed crescentic and necrotizing glomerulonephritis (GN) with membranoproliferative GN features [double contour appearance of the glomerular basement membrane, granular deposition of immunoglobulin (Ig) G, IgM, and C3 along the capillary wall, subendothelial and subepithelial deposits with mesangial interposition]. A potential relationship between MPO-ANCA associated GN and membranoproliferative GN is discussed.</description><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Aged</subject><subject>Antibodies, Antineutrophil Cytoplasmic - analysis</subject><subject>antineutrophil cytoplasmic antibody (ANCA)</subject><subject>antinuclear antibody (ANA)</subject><subject>crescentic glomerulonephritis</subject><subject>Glomerulonephritis - drug therapy</subject><subject>Glomerulonephritis - immunology</subject><subject>Glomerulonephritis - pathology</subject><subject>Glomerulonephritis, Membranoproliferative - drug therapy</subject><subject>Glomerulonephritis, Membranoproliferative - immunology</subject><subject>Glomerulonephritis, Membranoproliferative - pathology</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Male</subject><subject>membranoproliferative glomerulonephritis</subject><subject>myeloperoxidase (MPO)</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkcGO0zAQhi0EYsvCKyAfu4eU2E7s5BhFbBdp23KAc-Q4k61XThxsZ6G8Di-6Li09IA5cxof55h_bH0KYpCtKePlBjwHcKM0AnVZ6hFWer3hG-Qu0ICwrE0FZ_hIt0pIUCY3lCr3x_jFNWSFK-hpdUZEJkRG6QL82BzB2Amd_6E56wNUYYuAcnJ322uD6EOxkpB-0-t1qbXfAy83nXVJt6-oGV95bpWWADtcOvILIKCzHDm9BORv0Tz0-4LWxA7jZ2BGmvdNBe7xcb2_wdx32eAND6-RoJ2eN7sHJoJ8Ar7f4FmSYY-hb9KqXxsO783mNvt5-_FLfJfe79ae6uk9UnuYhkYxnHFRHCekFgbbrWScol10hhSCKFlme8VL0ueCKRpC2VMkiZT3hTPEsZddoecqNN_k2gw_NoOOLjJEj2Nk3pGCClkKU7D_QtGAFpRmPaHFC43d476BvJqcH6Q4NSZujzeZvm02eN0ebcfT9ecvcxuZl8I--COxOwKMP8gEugHTRgoF_JpP8WM8rLqTaS9fAyJ4BOT7A4Q</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Koda, Ryo</creator><creator>Nagahori, Katsuhiro</creator><creator>Kitazawa, Atsushi</creator><creator>Imanishi, Yuji</creator><creator>Yoshino, Atsunori</creator><creator>Kawamoto, Shinya</creator><creator>Ueda, Yoshihiko</creator><creator>Takeda, Tetsuro</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20160101</creationdate><title>Myeloperoxidase Antineutrophil Cytoplasmic Antibody (MPO-ANCA) Associated Crescentic and Necrotizing Glomerulonephritis (GN) with Membranoproliferative GN Features</title><author>Koda, Ryo ; 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subjects	Adrenal Cortex Hormones - therapeutic use Aged Antibodies, Antineutrophil Cytoplasmic - analysis antineutrophil cytoplasmic antibody (ANCA) antinuclear antibody (ANA) crescentic glomerulonephritis Glomerulonephritis - drug therapy Glomerulonephritis - immunology Glomerulonephritis - pathology Glomerulonephritis, Membranoproliferative - drug therapy Glomerulonephritis, Membranoproliferative - immunology Glomerulonephritis, Membranoproliferative - pathology Humans Immunosuppressive Agents - therapeutic use Male membranoproliferative glomerulonephritis myeloperoxidase (MPO)
title	Myeloperoxidase Antineutrophil Cytoplasmic Antibody (MPO-ANCA) Associated Crescentic and Necrotizing Glomerulonephritis (GN) with Membranoproliferative GN Features
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