Synthesis of novel nicotinohydrazide and (1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridine derivatives as potential anticancer agents

A series of novel nicotinohydrazide and (1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridine derivatives 6a–j, 7a–k and 8a–d were prepared and screened for the anticancer activity against four human cancer cell lines, compounds 6h, 6i, 7d, 7h, 7i and 8b which showed highest activity against DU145 (pro...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2016-10, Vol.26 (19), p.4829-4831
Main Authors: Naresh Kumar, R., Poornachandra, Y., Nagender, P., Santhosh Kumar, G., Krishna Swaroop, D., Ganesh Kumar, C., Narsaiah, B.
Format: Article
Language:English
Subjects:
1,3,4-Oxadiazole
Anticancer agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Cyclization
Drug Screening Assays, Antitumor
Human cancer cell lines
Humans
Nicotinohydrazide
Pyridines - chemical synthesis
Pyridines - pharmacology
Structure-Activity Relationship
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of novel nicotinohydrazide and (1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridine derivatives 6a–j, 7a–k and 8a–d were prepared and screened for the anticancer activity against four human cancer cell lines, compounds 6h, 6i, 7d, 7h, 7i and 8b which showed highest activity against DU145 (prostate) cell line have been identified. [Display omitted] A series of novel nicotinohydrazide derivatives 6a–g and 1,3,4-oxadiazole functionalized pyridine derivatives 7a–k and 8a–d were prepared in series of steps. All the compounds were screened for cytotoxicity against HeLa (cervical), DU145 (prostate), HepG2 (liver) and MBA-MB-231 (breast) human cancer cell lines. Compounds 6h, 6i, 7d, 7h, 7i and 8b which showed promising cytotoxicity at
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2016.08.020