Clinical improvement in feline herpesvirus 1 infected cats by oral low dose of interleukin-12 plus interferon-gamma

Highlights • Low-doses of SKA IL-12 plus IFN-gamma induced a general improvement of several clinical signs in FHV-1 infected cats. • A high number of FHV-1-positive cats being rendered PCR negative after the treatment with low-doses of cytokines. • Low dose cytokines therapy could be an alternative...

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Bibliographic Details
Published in:Comparative immunology, microbiology and infectious diseases microbiology and infectious diseases, 2016-10, Vol.48, p.41-47
Main Authors: Fiorito, Filomena, Cantiello, Antonietta, Granato, Giovanna Elvira, Navas, Luigi, Diffidenti, Carmine, De Martino, Luisa, Maharajan, Veeramani, Olivieri, Fabio, Pagnini, Ugo, Iovane, Giuseppe
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - therapeutic use
Administration, Oral
Allergy and Immunology
Animals
Antiviral Agents - administration & dosage
Antiviral Agents - therapeutic use
Cat Diseases - drug therapy
Cat Diseases - virology
Cats
Clinical trial
Conjunctivitis, Viral - drug therapy
Conjunctivitis, Viral - veterinary
DNA, Viral
Drug Therapy, Combination
Feline herpesvirus-1
Herpesviridae
Herpesviridae Infections - drug therapy
Herpesviridae Infections - veterinary
Herpesviridae Infections - virology
Herpesvirus 1, Suid
Infectious Disease
Interferon-gamma - administration & dosage
Interferon-gamma - therapeutic use
Interleukin-12 - administration & dosage
Interleukin-12 - therapeutic use
Interleukin-12 plus interferon-gamma
Low dose therapy
Polymerase Chain Reaction
Prospective Studies
Sequential Kinetic ActivationSequential kinetic activation
Virus Shedding
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Summary:Highlights • Low-doses of SKA IL-12 plus IFN-gamma induced a general improvement of several clinical signs in FHV-1 infected cats. • A high number of FHV-1-positive cats being rendered PCR negative after the treatment with low-doses of cytokines. • Low dose cytokines therapy could be an alternative to traditional antiviral therapy to treat FHV-1 infection in cats.
ISSN:0147-9571
1878-1667
DOI:10.1016/j.cimid.2016.07.006