Increased risk of obesity related to total energy intake with the APOA5 -1131T > C polymorphism in Korean premenopausal women

Abstract We hypothesized that triglyceride-raising apolipoprotein A5 ( APOA5 )-1131T > C may contribute to the increased risk of obesity associated with dietary intake in Korean premenopausal women whose minor allele frequency is higher than that in Western people. Genetically unrelated Korean pr...

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Bibliographic Details
Published in:Nutrition research (New York, N.Y.) N.Y.), 2014-10, Vol.34 (10), p.827-836
Main Authors: Lim, Hyo Hee, Choi, Miok, Kim, Ji Young, Lee, Jong Ho, Kim, Oh Yoen
Format: Article
Language:English
Subjects:
Adult
Anthropometry
APOA5-1131T > C
Apolipoprotein A-V
Apolipoproteins A - blood
Apolipoproteins A - genetics
Asian Continental Ancestry Group - genetics
Body Mass Index
Cholesterol, HDL - blood
Cholesterol, HDL - genetics
Diet
Energy Intake
Energy Metabolism
Female
Gastroenterology and Hepatology
Gene Frequency
Genotype
Homozygote
Human
Humans
Obesity
Obesity - genetics
Odds Ratio
Polymorphism, Single Nucleotide
Premenopause
Republic of Korea
Risk
Total energy intake
Triglycerides - blood
Triglycerides - genetics
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Summary:Abstract We hypothesized that triglyceride-raising apolipoprotein A5 ( APOA5 )-1131T > C may contribute to the increased risk of obesity associated with dietary intake in Korean premenopausal women whose minor allele frequency is higher than that in Western people. Genetically unrelated Korean premenopausal women (approximately 20-59 years, n = 1128) were genotyped for APOA5 -1131T > C. Anthropometric, metabolic parameters and dietary intakes were analyzed. Odds ratios (ORs) for obesity risk (body mass index, ≥25.0 kg/m2 ) were calculated. Genotype distribution of APOA5 -1131T > C of study subjects were like TT: 49.9%, TC: 40.8%, and CC: 9.3%. We found a significant interaction between APOA5 -1131T > C and total energy intake (TEI) for obesity after adjusted for age, cigarette smoking, and alcohol consumption ( P < .001). The risk of obesity in CC homozygotes compared with T carriers (TT + TC) was significantly increased, when the subjects consume higher TEI (≥2001 kcal/d (8372 kJ/d), median value of the population) (OR, 2.495; 95% confidence intervals, 1.325-4.696; P = .005), particularly, when they maintain negative balance between total energy expenditure and TEI (total energy expenditure/TEI,
ISSN:0271-5317
1879-0739
DOI:10.1016/j.nutres.2014.08.018