Abstract 3040: A novel methoxyflavanone from a Chinese medicinal herb (Perilla frutescens) induces G2M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma cells

Background: Perilla frutescens is a common traditional Chinese medicinal herb used for a variety of diseases, e.g. allergic asthma, cough and intestinal disorders. Flavonoids isolated from P. frutescens such as rosmarinic acid, caffeic acid and apigenin have been reported to inhibit proliferation of...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2016-07, Vol.76 (14_Supplement), p.3040-3040
Main Authors: Mohamed, Amer Ali Abd El Hafeez, Fujimura, Takashi, Kamei, Rikiya, Hirakawa, Noriko, Baba, Kenji, Nakano, Miyako, Ono, Kazuhisa, Kawamoto, Seiji
Format: Article
Language:English
Subjects:
Perilla frutescens
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Summary:Background: Perilla frutescens is a common traditional Chinese medicinal herb used for a variety of diseases, e.g. allergic asthma, cough and intestinal disorders. Flavonoids isolated from P. frutescens such as rosmarinic acid, caffeic acid and apigenin have been reported to inhibit proliferation of a variety of cancer cell lines. We recently identified a novel methoxyflavanone named PDMF (Perilla-derived methoxyflavanone) from P. frutescens as a candidate for anti-allergic drug. The objective of the study is to investigate antitumor potency of PDMF on A549 human lung adenocarcinoma and to elucidate its carcinostatic mechanisms.
ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM2016-3040