iTRAQ-based quantitative proteomics of stratum corneum of dandruff scalp reveals new insights into its aetiology and similarities with atopic dermatitis

The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their k...

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Bibliographic Details
Published in:Archives of Dermatological Research 2016-11, Vol.308 (9), p.631-642
Main Authors: Cavusoglu, Nükhet, Delattre, Caroline, Donovan, Mark, Bourassa, Sylvie, Droit, Arnaud, El Rawadi, Charles, Jourdain, Roland, Bernard, Dominique
Format: Article
Language:English
Subjects:
Adult
Cell Differentiation
Dermatitis, Atopic - metabolism
Dermatitis, Seborrheic - etiology
Dermatitis, Seborrheic - metabolism
Dermatology
Epidermis - metabolism
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Original Paper
Proteomics - methods
Scalp - metabolism
Skin - metabolism
Tandem Mass Spectrometry
Young Adult
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Summary:The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological functions provided new insights into the affected metabolic pathways of a dandruff scalp. Dandruff scalp showed (1) profound changes in the expression and maturation of structural and epidermal differentiation related proteins, that are responsible for the integrity of the skin, (2) altered relevant factors that regulate skin hydration, and (3) an imbalanced physiological protease–protease inhibitor ratio. Stratum corneum proteins with antimicrobial activity, mainly those derived from sweat and sebaceous glands were also found modified. Comparing our data with those reported for atopic dermatitis revealed that about 50 % of the differentially expressed proteins in the superficial layers of the stratum corneum from dandruff and atopic dermatitis are identical.
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-016-1681-4