Comparison of myelin water fraction values in periventricular white matter lesions between multiple sclerosis and neuromyelitis optica spectrum disorder

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory autoimmune diseases of the central nervous system. We hypothesized that the degree of demyelination within lesions in MS and NMOSD would differ as the pathophysiology of the two diseases do. We used myelin wa...

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Bibliographic Details
Published in:Multiple sclerosis 2016-10, Vol.22 (12), p.1616-1620
Main Authors: Jeong, In Hye, Choi, Joon Yul, Kim, Su-Hyun, Hyun, Jae-Won, Joung, AeRan, Lee, Jongho, Kim, Ho Jin
Format: Article
Language:English
Subjects:
Adult
Humans
Magnetic Resonance Imaging - methods
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - pathology
Myelin Sheath - pathology
Neuromyelitis Optica - diagnostic imaging
Neuromyelitis Optica - pathology
Water - metabolism
White Matter - diagnostic imaging
White Matter - pathology
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Summary:Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory autoimmune diseases of the central nervous system. We hypothesized that the degree of demyelination within lesions in MS and NMOSD would differ as the pathophysiology of the two diseases do. We used myelin water imaging to compare the myelin water fraction (MWF) in 106 periventricular white matter (PVWM) lesions in 27 MS patients and 51 PVWM lesions in 20 NMOSD patients. The MWF was significantly reduced in the MS compared with the NMOSD lesions, suggesting that myelin loss was more severe in MS than in NMOSD.
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458516636247