The middle-aged ovariectomized marmoset ( Callithrix jacchus ) as a model of menopausal symptoms: Preliminary evidence

Highlights • Estradiol (E2) replacement decreases nighttime core body temperature in the OVX female marmoset. • E2 replacement decreases the number of nighttime arousals. • E2 replacement increases delta power, a marker of sleep quality. • The OVX marmoset is a promising model for studying menopausa...

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Bibliographic Details
Published in:Neuroscience 2016-11, Vol.337, p.1-8
Main Authors: Gervais, Nicole J, Viechweg, Shaun S, Mong, Jessica A, Lacreuse, Agnès
Format: Article
Language:English
Subjects:
Aging
Animals
Body Temperature Regulation - physiology
Callithrix
Callithrix jacchus
Disease Models, Animal
Electroencephalography - methods
Estradiol - metabolism
Estrogens - metabolism
Female
Hot Flashes
menopause
Menopause - physiology
monkey
Neurology
Ovariectomy
primate
sleep
Sleep - physiology
Sleep Wake Disorders - physiopathology
temperature
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Summary:Highlights • Estradiol (E2) replacement decreases nighttime core body temperature in the OVX female marmoset. • E2 replacement decreases the number of nighttime arousals. • E2 replacement increases delta power, a marker of sleep quality. • The OVX marmoset is a promising model for studying menopausal symptoms such as sleep disturbances and thermodysregulation.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.08.056