Thermotolerance of an inactivated rabies vaccine for dogs

Highlights • Assessment of dogs inoculated with Nobivac Rabies vaccine stored at high temperatures. • Neutralizing antibody response not inferior after vaccine stored at 30 °C for 3 months. • Nobivac Rabies vaccine likely to be efficacious if exposed to elevated temperatures. • Flexible vaccine deli...

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Bibliographic Details
Published in:Vaccine 2016-11, Vol.34 (46), p.5504-5511
Main Authors: Lankester, Felix J, Wouters, Pieter A.W.M, Czupryna, Anna, Palmer, Guy H, Mzimbiri, Imam, Cleaveland, Sarah, Francis, Mike J, Sutton, David J, Sonnemans, Denny G.P
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies, Neutralizing - blood
Antibodies, Neutralizing - immunology
Antibodies, Viral - blood
Antibodies, Viral - immunology
Canine-mediated human rabies
Cold
Cold-chain
Disease control
Dog Diseases - prevention & control
Dogs
Drug Storage
High temperature
Hot Temperature
Immunization
Non-inferiority trial
Rabies
Rabies - prevention & control
Rabies - veterinary
Rabies Vaccines - administration & dosage
Rabies Vaccines - immunology
Rabies virus - immunology
Tanzania
Thermo-tolerance
Thermotolerance
Vaccination - veterinary
Vaccine
Vaccine Potency
Vaccine storage
Vaccines
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - immunology
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Summary:Highlights • Assessment of dogs inoculated with Nobivac Rabies vaccine stored at high temperatures. • Neutralizing antibody response not inferior after vaccine stored at 30 °C for 3 months. • Nobivac Rabies vaccine likely to be efficacious if exposed to elevated temperatures. • Flexible vaccine delivery models can be explored using the Nobivac Rabies vaccine.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.10.015