CB1 cannabinoid receptor-mediated anandamide signaling mechanisms of the inferior colliculus modulate the haloperidol-induced catalepsy

Highlights • The IC plays a role in sensorimotor gating and endocannabinoid mechanisms are involved. • AEA injected in the IC can increase systemic haloperidol-induced catalepsy. • Systemic haloperidol-induced catalepsy is reduced by AM251 injected in the IC.

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Bibliographic Details
Published in:Neuroscience 2016-11, Vol.337, p.17-26
Main Authors: Medeiros, P, de Freitas, R.L, Silva, M.O, Coimbra, N.C, Melo-Thomas, L
Format: Article
Language:English
Subjects:
AM251
anandamide
Animals
Arachidonic Acids - pharmacology
Cannabinoids - pharmacology
Catalepsy - chemically induced
Catalepsy - drug therapy
CB1 cannabinoid receptor
Dopamine Antagonists - pharmacology
endocannabinoids
Endocannabinoids - pharmacology
Haloperidol - pharmacology
haloperidol catalepsy
Inferior Colliculi - drug effects
inferior colliculus
Male
Neurology
Polyunsaturated Alkamides - pharmacology
Rats, Wistar
Receptor, Cannabinoid, CB1 - drug effects
Receptor, Cannabinoid, CB1 - metabolism
Signal Transduction - drug effects
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Description
Summary:Highlights • The IC plays a role in sensorimotor gating and endocannabinoid mechanisms are involved. • AEA injected in the IC can increase systemic haloperidol-induced catalepsy. • Systemic haloperidol-induced catalepsy is reduced by AM251 injected in the IC.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.08.047