Impaired Neurodevelopmental Outcome After Mild Germinal Matrix-Intraventricular Hemorrhage

Germinal matrix-intraventricular hemorrhage (GMH-IVH) is a common and characteristic form of intracranial hemorrhage occurring in the premature infant. The hemorrhage originates in small blood vessels in the subependymal germinal matrix (also termed the ganglionic eminence) and may disrupt the epend...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2015-12, Vol.136 (6), p.1185-1187
Main Author: Volpe, Joseph J
Format: Article
Language:English
Subjects:
Cerebral Hemorrhage - complications
Cognition Disorders - etiology
Developmental Disabilities - etiology
Hemorrhage
Humans
Meta-analysis
Neurological disorders
Pediatrics
Premature birth
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Summary:Germinal matrix-intraventricular hemorrhage (GMH-IVH) is a common and characteristic form of intracranial hemorrhage occurring in the premature infant. The hemorrhage originates in small blood vessels in the subependymal germinal matrix (also termed the ganglionic eminence) and may disrupt the ependymal lining and extend into the lateral ventricle. Severe IVH consists of large amounts of intraventricular blood (usually termed grade 3 IVH) and may be complicated by hemorrhagic venous infarction in the periventricular white matter (often termed grade 4 IVH) or by post-hemorrhagic hydrocephalus or both. Many studies have documented increased short-term and long-term neurologic morbidity after severe IVH. In their study, Mukerji et al report the first meta-analysis of neurodevelopmental outcomes after GMH-IVH (termed periventricular/intraventricular hemorrhage).
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2015-3553