Primary Marginal Zone Lymphoma in the Posterior Mediastinum with Pleural Involvement

We herein report a case of primary marginal zone lymphoma (MZL) of the posterior mediastinum in an 84-year-old woman. Computed tomography of the chest showed a posterior mediastinal mass in the right thoracic paravertebral region with right pleural effusion. Pathological findings of a surgical biops...

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Bibliographic Details
Published in:Internal Medicine 2016/09/15, Vol.55(18), pp.2673-2677
Main Authors: Shimizu, Shigeki, Inoue, Yasushi, Utsumi, Tomoki, Okuma, Tomohisa, Kawaguchi, Tomoya, Kasai, Takahiko, Munakata, Satoru, Shibano, Masaru, Atagi, Shinji
Format: Article
Language:English
Subjects:
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Antineoplastic Combined Chemotherapy Protocols
Biopsy
chemotherapy
Etoposide - therapeutic use
Female
Humans
Immunohistochemistry
Lymphoma, B-Cell, Marginal Zone - diagnostic imaging
Lymphoma, B-Cell, Marginal Zone - drug therapy
Lymphoma, B-Cell, Marginal Zone - pathology
malignant lymphoma
marginal zone lymphoma
Mediastinal Neoplasms - diagnostic imaging
Mediastinal Neoplasms - drug therapy
Mediastinal Neoplasms - pathology
Mediastinum - pathology
Neoplasm Recurrence, Local
Piperazines - therapeutic use
Pleura - pathology
pleural effusion
posterior mediastinum
Remission Induction
Tomography, X-Ray Computed
Treatment Outcome
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Summary:We herein report a case of primary marginal zone lymphoma (MZL) of the posterior mediastinum in an 84-year-old woman. Computed tomography of the chest showed a posterior mediastinal mass in the right thoracic paravertebral region with right pleural effusion. Pathological findings of a surgical biopsy from the posterior mediastinum, along with immunohistochemical and flow cytometric results, indicated MZL. The patient was treated with chemotherapy and radiation therapy for the mediastinal lesion and achieved complete remission. A relapse occurred 3 months after the initial treatment regimen. However, a second relapse has not occurred more than 2 years after second-line chemotherapy. This is the first case of MZL originating in the posterior mediastinum.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.55.6716