Meta-Analysis of the Usefulness of Change in QRS Width to Predict Response to Cardiac Resynchronization Therapy

The existing data regarding the role of QRS duration (QRSd) change on cardiac resynchronization therapy (CRT) response show some inconsistent results. We conducted a meta-analysis of data obtained from observational studies to examine the impact of QRS change after CRT device implantation on the cli...

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Bibliographic Details
Published in:The American journal of cardiology 2016-11, Vol.118 (9), p.1368-1373
Main Authors: Korantzopoulos, Panagiotis, MD, PhD, Zhang, Zhiwei, MD, Li, Guangping, MD, PhD, Fragakis, Nikolaos, MD, PhD, Liu, Tong, MD, PhD
Format: Article
Language:English
Subjects:
Cardiac Resynchronization Therapy
Cardiovascular
Echocardiography
Heart Conduction System - physiopathology
Humans
Meta-analysis
Patients
Predictive Value of Tests
Studies
Ventricular Dysfunction, Left - physiopathology
Ventricular Dysfunction, Left - therapy
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Summary:The existing data regarding the role of QRS duration (QRSd) change on cardiac resynchronization therapy (CRT) response show some inconsistent results. We conducted a meta-analysis of data obtained from observational studies to examine the impact of QRS change after CRT device implantation on the clinical and/or echocardiographic response. We searched the PubMed and EMBASE databases for relevant studies published before January 2016. Twenty-seven studies were retrieved for detailed evaluation of which 12 studies with a total population of 1,545 patients met our eligibility criteria. The analysis demonstrated that QRSd narrowing was a positive predictor of response to CRT (mean difference [MD] = −19.24 ms, 95% CI = −24.00 to −14.48 ms, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2016.07.070