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Serial procalcitonin levels for predicting prognosis in community-acquired pneumonia
ABSTRACT Background and objective This study aimed to investigate the usefulness of addition of serial measurements of procalcitonin (PCT) to C‐reactive protein (CRP) values and pneumonia severity scores, such as CURB‐65 (confusion, urea > 7 mmol/L, respiratory rate ≥ 30 breaths/min, low blood pr...
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| Published in: | Respirology (Carlton, Vic.) Vic.), 2016-11, Vol.21 (8), p.1459-1464 |
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| container_title | Respirology (Carlton, Vic.) |
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| creator | Ito, Akihiro Ishida, Tadashi Tachibana, Hiromasa Ito, Yuhei Takaiwa, Takuya |
| description | ABSTRACT
Background and objective
This study aimed to investigate the usefulness of addition of serial measurements of procalcitonin (PCT) to C‐reactive protein (CRP) values and pneumonia severity scores, such as CURB‐65 (confusion, urea > 7 mmol/L, respiratory rate ≥ 30 breaths/min, low blood pressure (systolic |
| doi_str_mv | 10.1111/resp.12846 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1837322239</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1826714803</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4666-894c9c82906a523c13a71466b9948ca59eb26690050408be213d92a8dceebcc03</originalsourceid><addsrcrecordid>eNqNkEtLAzEUhYMoVqsbf4DMUoTRPGYyyVJKfVHqo4riJmTS2xKdR01m1P57U0ddineTC_c7J4eD0B7BRyTMsQO_OCJUJHwNbZEkwTERCVsPO6MszjIpe2jb-2eMMUtxuol6NGNSyERsobsJOKuLaOFqowtjm7qyVVTAGxQ-mtUuHGBqTWOr-YqZV7W3PgqIqcuyrWyzjLV5bW2gokUFbRn0egdtzHThYff77aP70-Hd4DweXZ1dDE5GsUk453FIYKQRVGKuU8oMYToj4ZLLEM3oVEJOOZcYpzjBIgdK2FRSLaYGIDcGsz466HxDstcWfKNK6w0Uha6gbr0igmWMUsrkP1DKw-cCs4AedqhxtfcOZmrhbKndUhGsVoWrVeHqq_AA73_7tnkJ01_0p-EAkA54twUs_7BSt8PJ9Y9p3Gmsb-DjV6Pdi-IZy1L1MD5TN5KNB4_Jk7pkn3PgmuU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1826714803</pqid></control><display><type>article</type><title>Serial procalcitonin levels for predicting prognosis in community-acquired pneumonia</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Ito, Akihiro ; Ishida, Tadashi ; Tachibana, Hiromasa ; Ito, Yuhei ; Takaiwa, Takuya</creator><creatorcontrib>Ito, Akihiro ; Ishida, Tadashi ; Tachibana, Hiromasa ; Ito, Yuhei ; Takaiwa, Takuya</creatorcontrib><description>ABSTRACT
Background and objective
This study aimed to investigate the usefulness of addition of serial measurements of procalcitonin (PCT) to C‐reactive protein (CRP) values and pneumonia severity scores, such as CURB‐65 (confusion, urea > 7 mmol/L, respiratory rate ≥ 30 breaths/min, low blood pressure (systolic < 90 mm Hg or diastolic ≤ 60 mm Hg) and age ≥ 65 years) and the Pneumonia Severity Index, and attempted to create and evaluate a new scoring system for predicting mortality risk using the biomarkers and pneumonia severity scores.
Methods
A total of 365 hospitalized community‐acquired pneumonia (CAP) patients in an observational cohort study in which PCT was measured serially from admission to 2–3 days after admission between December 2010 and December 2014 were reviewed retrospectively. PCT and CRP were measured on admission (PCT D1 and CRP D1) and within 48–72 h after admission (PCT D3 and CRP D3).
Results
Twenty‐one patients died (5.8%), and 52 patients (14.2%) did not respond to initial therapy. On multivariate analysis, CRP D1 ≥ 100 mg/L (P = 0.002), CURB‐65 ≥ 3 (P < 0.001) and PCT D3/D1 ≥ 1 (P < 0.001) were significant predictors of 30‐day mortality. Peak CRP (P = 0.02) and PCT D3/D1 ≥ 1 (P = 0.03) were significant predictors of initial treatment failure. Using the new scoring system that defines CRP D1 ≥ 100 mg/L as 2 points, CURB‐65 ≥ 3 as 1 point and PCT D3/D1 ≥ 1 as 1 point, in CAP patients with both CRP D1 ≥ 100 mg/L and CURB‐65 ≥ 3 on admission, the 30‐day mortality rate was 21.8%, and with PCT D3/D1 ≥ 1, it increased to 50.0%.
Conclusion
It is useful to add serial measurements of PCT to CRP measurement and assessment of CURB‐65 on admission of CAP patients to predict prognosis and initial treatment failure.
The usefulness of serial procalcitonin (PCT) measurements for predicting prognosis and initial treatment failure in community‐acquired pneumonia (CAP) patients was shown. Addition of consecutive measurements of PCT starting from admission to measurements of C‐reactive protein and assessment of CURB‐65 (confusion, urea > 7 mmol/L, respiratory rate ≥ 30 breaths/min, low blood pressure (systolic < 90 mm Hg or diastolic ≤ 60 mm Hg) and age ≥ 65 years) improves the prediction of prognosis and initial treatment failure in CAP patients.</description><identifier>ISSN: 1323-7799</identifier><identifier>EISSN: 1440-1843</identifier><identifier>DOI: 10.1111/resp.12846</identifier><identifier>PMID: 27398948</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Aged ; Biomarkers - analysis ; Biomarkers - blood ; C-reactive protein ; C-Reactive Protein - analysis ; Calcitonin - analysis ; Calcitonin - blood ; Cohort Studies ; Community-Acquired Infections - blood ; Community-Acquired Infections - diagnosis ; Community-Acquired Infections - mortality ; community-acquired pneumonia ; CURB-65 ; Female ; Hospitalization - statistics & numerical data ; Humans ; Japan - epidemiology ; Male ; Pneumonia - blood ; Pneumonia - diagnosis ; Pneumonia - mortality ; Predictive Value of Tests ; procalcitonin ; Prognosis ; Research Design ; Retrospective Studies ; Severity of Illness Index</subject><ispartof>Respirology (Carlton, Vic.), 2016-11, Vol.21 (8), p.1459-1464</ispartof><rights>2016 Asian Pacific Society of Respirology</rights><rights>2016 Asian Pacific Society of Respirology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4666-894c9c82906a523c13a71466b9948ca59eb26690050408be213d92a8dceebcc03</citedby><cites>FETCH-LOGICAL-c4666-894c9c82906a523c13a71466b9948ca59eb26690050408be213d92a8dceebcc03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27398948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Akihiro</creatorcontrib><creatorcontrib>Ishida, Tadashi</creatorcontrib><creatorcontrib>Tachibana, Hiromasa</creatorcontrib><creatorcontrib>Ito, Yuhei</creatorcontrib><creatorcontrib>Takaiwa, Takuya</creatorcontrib><title>Serial procalcitonin levels for predicting prognosis in community-acquired pneumonia</title><title>Respirology (Carlton, Vic.)</title><addtitle>Respirology</addtitle><description>ABSTRACT
Background and objective
This study aimed to investigate the usefulness of addition of serial measurements of procalcitonin (PCT) to C‐reactive protein (CRP) values and pneumonia severity scores, such as CURB‐65 (confusion, urea > 7 mmol/L, respiratory rate ≥ 30 breaths/min, low blood pressure (systolic < 90 mm Hg or diastolic ≤ 60 mm Hg) and age ≥ 65 years) and the Pneumonia Severity Index, and attempted to create and evaluate a new scoring system for predicting mortality risk using the biomarkers and pneumonia severity scores.
Methods
A total of 365 hospitalized community‐acquired pneumonia (CAP) patients in an observational cohort study in which PCT was measured serially from admission to 2–3 days after admission between December 2010 and December 2014 were reviewed retrospectively. PCT and CRP were measured on admission (PCT D1 and CRP D1) and within 48–72 h after admission (PCT D3 and CRP D3).
Results
Twenty‐one patients died (5.8%), and 52 patients (14.2%) did not respond to initial therapy. On multivariate analysis, CRP D1 ≥ 100 mg/L (P = 0.002), CURB‐65 ≥ 3 (P < 0.001) and PCT D3/D1 ≥ 1 (P < 0.001) were significant predictors of 30‐day mortality. Peak CRP (P = 0.02) and PCT D3/D1 ≥ 1 (P = 0.03) were significant predictors of initial treatment failure. Using the new scoring system that defines CRP D1 ≥ 100 mg/L as 2 points, CURB‐65 ≥ 3 as 1 point and PCT D3/D1 ≥ 1 as 1 point, in CAP patients with both CRP D1 ≥ 100 mg/L and CURB‐65 ≥ 3 on admission, the 30‐day mortality rate was 21.8%, and with PCT D3/D1 ≥ 1, it increased to 50.0%.
Conclusion
It is useful to add serial measurements of PCT to CRP measurement and assessment of CURB‐65 on admission of CAP patients to predict prognosis and initial treatment failure.
The usefulness of serial procalcitonin (PCT) measurements for predicting prognosis and initial treatment failure in community‐acquired pneumonia (CAP) patients was shown. Addition of consecutive measurements of PCT starting from admission to measurements of C‐reactive protein and assessment of CURB‐65 (confusion, urea > 7 mmol/L, respiratory rate ≥ 30 breaths/min, low blood pressure (systolic < 90 mm Hg or diastolic ≤ 60 mm Hg) and age ≥ 65 years) improves the prediction of prognosis and initial treatment failure in CAP patients.</description><subject>Aged</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - blood</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Calcitonin - analysis</subject><subject>Calcitonin - blood</subject><subject>Cohort Studies</subject><subject>Community-Acquired Infections - blood</subject><subject>Community-Acquired Infections - diagnosis</subject><subject>Community-Acquired Infections - mortality</subject><subject>community-acquired pneumonia</subject><subject>CURB-65</subject><subject>Female</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Pneumonia - blood</subject><subject>Pneumonia - diagnosis</subject><subject>Pneumonia - mortality</subject><subject>Predictive Value of Tests</subject><subject>procalcitonin</subject><subject>Prognosis</subject><subject>Research Design</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><issn>1323-7799</issn><issn>1440-1843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkEtLAzEUhYMoVqsbf4DMUoTRPGYyyVJKfVHqo4riJmTS2xKdR01m1P57U0ddineTC_c7J4eD0B7BRyTMsQO_OCJUJHwNbZEkwTERCVsPO6MszjIpe2jb-2eMMUtxuol6NGNSyERsobsJOKuLaOFqowtjm7qyVVTAGxQ-mtUuHGBqTWOr-YqZV7W3PgqIqcuyrWyzjLV5bW2gokUFbRn0egdtzHThYff77aP70-Hd4DweXZ1dDE5GsUk453FIYKQRVGKuU8oMYToj4ZLLEM3oVEJOOZcYpzjBIgdK2FRSLaYGIDcGsz466HxDstcWfKNK6w0Uha6gbr0igmWMUsrkP1DKw-cCs4AedqhxtfcOZmrhbKndUhGsVoWrVeHqq_AA73_7tnkJ01_0p-EAkA54twUs_7BSt8PJ9Y9p3Gmsb-DjV6Pdi-IZy1L1MD5TN5KNB4_Jk7pkn3PgmuU</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Ito, Akihiro</creator><creator>Ishida, Tadashi</creator><creator>Tachibana, Hiromasa</creator><creator>Ito, Yuhei</creator><creator>Takaiwa, Takuya</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201611</creationdate><title>Serial procalcitonin levels for predicting prognosis in community-acquired pneumonia</title><author>Ito, Akihiro ; Ishida, Tadashi ; Tachibana, Hiromasa ; Ito, Yuhei ; Takaiwa, Takuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4666-894c9c82906a523c13a71466b9948ca59eb26690050408be213d92a8dceebcc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - blood</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Calcitonin - analysis</topic><topic>Calcitonin - blood</topic><topic>Cohort Studies</topic><topic>Community-Acquired Infections - blood</topic><topic>Community-Acquired Infections - diagnosis</topic><topic>Community-Acquired Infections - mortality</topic><topic>community-acquired pneumonia</topic><topic>CURB-65</topic><topic>Female</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Pneumonia - blood</topic><topic>Pneumonia - diagnosis</topic><topic>Pneumonia - mortality</topic><topic>Predictive Value of Tests</topic><topic>procalcitonin</topic><topic>Prognosis</topic><topic>Research Design</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Akihiro</creatorcontrib><creatorcontrib>Ishida, Tadashi</creatorcontrib><creatorcontrib>Tachibana, Hiromasa</creatorcontrib><creatorcontrib>Ito, Yuhei</creatorcontrib><creatorcontrib>Takaiwa, Takuya</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Respirology (Carlton, Vic.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Akihiro</au><au>Ishida, Tadashi</au><au>Tachibana, Hiromasa</au><au>Ito, Yuhei</au><au>Takaiwa, Takuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serial procalcitonin levels for predicting prognosis in community-acquired pneumonia</atitle><jtitle>Respirology (Carlton, Vic.)</jtitle><addtitle>Respirology</addtitle><date>2016-11</date><risdate>2016</risdate><volume>21</volume><issue>8</issue><spage>1459</spage><epage>1464</epage><pages>1459-1464</pages><issn>1323-7799</issn><eissn>1440-1843</eissn><abstract>ABSTRACT
Background and objective
This study aimed to investigate the usefulness of addition of serial measurements of procalcitonin (PCT) to C‐reactive protein (CRP) values and pneumonia severity scores, such as CURB‐65 (confusion, urea > 7 mmol/L, respiratory rate ≥ 30 breaths/min, low blood pressure (systolic < 90 mm Hg or diastolic ≤ 60 mm Hg) and age ≥ 65 years) and the Pneumonia Severity Index, and attempted to create and evaluate a new scoring system for predicting mortality risk using the biomarkers and pneumonia severity scores.
Methods
A total of 365 hospitalized community‐acquired pneumonia (CAP) patients in an observational cohort study in which PCT was measured serially from admission to 2–3 days after admission between December 2010 and December 2014 were reviewed retrospectively. PCT and CRP were measured on admission (PCT D1 and CRP D1) and within 48–72 h after admission (PCT D3 and CRP D3).
Results
Twenty‐one patients died (5.8%), and 52 patients (14.2%) did not respond to initial therapy. On multivariate analysis, CRP D1 ≥ 100 mg/L (P = 0.002), CURB‐65 ≥ 3 (P < 0.001) and PCT D3/D1 ≥ 1 (P < 0.001) were significant predictors of 30‐day mortality. Peak CRP (P = 0.02) and PCT D3/D1 ≥ 1 (P = 0.03) were significant predictors of initial treatment failure. Using the new scoring system that defines CRP D1 ≥ 100 mg/L as 2 points, CURB‐65 ≥ 3 as 1 point and PCT D3/D1 ≥ 1 as 1 point, in CAP patients with both CRP D1 ≥ 100 mg/L and CURB‐65 ≥ 3 on admission, the 30‐day mortality rate was 21.8%, and with PCT D3/D1 ≥ 1, it increased to 50.0%.
Conclusion
It is useful to add serial measurements of PCT to CRP measurement and assessment of CURB‐65 on admission of CAP patients to predict prognosis and initial treatment failure.
The usefulness of serial procalcitonin (PCT) measurements for predicting prognosis and initial treatment failure in community‐acquired pneumonia (CAP) patients was shown. Addition of consecutive measurements of PCT starting from admission to measurements of C‐reactive protein and assessment of CURB‐65 (confusion, urea > 7 mmol/L, respiratory rate ≥ 30 breaths/min, low blood pressure (systolic < 90 mm Hg or diastolic ≤ 60 mm Hg) and age ≥ 65 years) improves the prediction of prognosis and initial treatment failure in CAP patients.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>27398948</pmid><doi>10.1111/resp.12846</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Biomarkers - analysis Biomarkers - blood C-reactive protein C-Reactive Protein - analysis Calcitonin - analysis Calcitonin - blood Cohort Studies Community-Acquired Infections - blood Community-Acquired Infections - diagnosis Community-Acquired Infections - mortality community-acquired pneumonia CURB-65 Female Hospitalization - statistics & numerical data Humans Japan - epidemiology Male Pneumonia - blood Pneumonia - diagnosis Pneumonia - mortality Predictive Value of Tests procalcitonin Prognosis Research Design Retrospective Studies Severity of Illness Index |
| title | Serial procalcitonin levels for predicting prognosis in community-acquired pneumonia |
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