MicroRNAs in adipose tissue: their role in adipogenesis and obesity

MicroRNAs (miRNAs) are endogenous small RNAs that posttranscriptionally regulate gene expression and that have been shown to have important roles in numerous disease processes. There is growing evidence for an important role of miRNAs in regulating the pathways in adipose tissue that control a range...

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Bibliographic Details
Published in:International Journal of Obesity 2013-03, Vol.37 (3), p.325-332
Main Authors: Hilton, C, Neville, M J, Karpe, F
Format: Article
Language:English
Subjects:
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Adipocytes
Adipogenesis
Adipose tissue
Adipose Tissue - metabolism
Adipose tissues
Biological and medical sciences
Biomarkers - metabolism
Blotting, Northern
Body fat
Cell Differentiation
Enzymes
Epidemiology
Female
Gene expression
Gene Expression Regulation
Genetic aspects
Health aspects
Health Promotion and Disease Prevention
Humans
Insects
Insulin Resistance
Internal Medicine
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic Syndrome - metabolism
Metabolism
MicroRNA
MicroRNAs
MicroRNAs - antagonists & inhibitors
MicroRNAs - metabolism
Obesity
Obesity - metabolism
Pathology
Proteins
Public Health
Real-Time Polymerase Chain Reaction
review
Risk factors
Stem cells
Tissue Array Analysis
Weight control
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Summary:MicroRNAs (miRNAs) are endogenous small RNAs that posttranscriptionally regulate gene expression and that have been shown to have important roles in numerous disease processes. There is growing evidence for an important role of miRNAs in regulating the pathways in adipose tissue that control a range of processes including adipogenesis, insulin resistance and inflammation. Several high-throughput studies have identified differentially expressed miRNAs in adipose tissue pathology and during adipogenesis and a number of these have now been characterised functionally in terms of their actions and targets. This review will summarise the current literature on miRNAs in adipose tissue, as well as discussing the methodologies used in this area of research and the potential application of miRNAs as biomarkers and as therapeutic targets.
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2012.59