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Spectral-domain optical coherence tomography reveals prelaminar membranes in optic nerve head pallor in eyes with retinitis pigmentosa
Purpose To determine the relationship between prelaminar structural changes of the optic nerve head (ONH) and optic nerve waxy pallor in retinitis pigmentosa (RP) using spectral-domain optical coherence tomography (SD-OCT) and fundus photography. Methods An observational cross-sectional case control...
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| Published in: | Graefe's archive for clinical and experimental ophthalmology 2016-01, Vol.254 (1), p.77-81 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
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| creator | Al Rashaed, Saba Khan, Arif O. Nowilaty, Sawsan R. Edward, Deepak P. Kozak, Igor |
| description | Purpose
To determine the relationship between prelaminar structural changes of the optic nerve head (ONH) and optic nerve waxy pallor in retinitis pigmentosa (RP) using spectral-domain optical coherence tomography (SD-OCT) and fundus photography.
Methods
An observational cross-sectional case control study of patients with RP with and without ONH waxy pallor and controls. Subjects underwent clinical examination, fundus photography, and SD-OCT raster imaging of the ONH. Four independent specialists reviewed the images in a masked fashion.
Results
Fifty-five eyes of 31 subjects with RP and 28 eyes of 14 controls were included. Optic nerve head waxy pallor was seen in 29 RP eyes (52.7 %) and none in controls. SD-OCT showed a hyper-reflective structure suggestive of a glial membrane-like structure on the surface of ONH in 16 of RP eyes (55.1 %). In the RP group, there was a significant positive correlation between the ONH pallor and the presence of a prelaminar structure (
p
= 0.006).
Conclusions
There is a presence of glial membrane-like structures on the optic nerve head surface in eyes with RP compared to healthy eyes. As the presence of glial membranes correlated with the presence of ONH waxy pallor, in such cases these membranes might be responsible for ONH waxy pallor. |
| doi_str_mv | 10.1007/s00417-015-3015-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1837324382</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1754084133</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-3e457f690fa97c41e6ca1d164a0241785b6f3c7c52eaaa8e622ccafbae17cb583</originalsourceid><addsrcrecordid>eNqFkc1u1DAURi0EokPLA7BBltiwCfX1T5xZogpapEosSqXuohvPzYyrOA52pmhegOfG0bQIISE29uKe71jXH2NvQHwAIex5FkKDrQSYSi0HPGMr0MpUVsi752wlrISqUfLuhL3K-V4UXBl4yU6kWQvRgFmxnzcTuTnhUG1iQD_yOM3e4cBd3FGi0RGfY4jbhNPuwBM9EA6ZT4kGDH7ExAOFLuFImT-F-UjpgfiOcMMnHIaYlhEdCvLDz7simf3oZ180fhtonGPGM_aiL2J6_XifstvPn75dXFXXXy-_XHy8rpy2Zq4UaWP7ei16XFungWqHsIFao5DlJxrT1b1y1hlJiNhQLaVz2HdIYF1nGnXK3h-9U4rf95TnNvjsaBjKBnGfW2iUVVKrRv4ftUaLRoNSBX33F3of92ksiyyUgkZbsVBwpFyKOSfq2yn5gOnQgmiXPttjn22psl36bKFk3j6a912gze_EU4EFkEcgl9G4pfTH0_-0_gLhIa1j</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1753184703</pqid></control><display><type>article</type><title>Spectral-domain optical coherence tomography reveals prelaminar membranes in optic nerve head pallor in eyes with retinitis pigmentosa</title><source>Springer Link</source><creator>Al Rashaed, Saba ; Khan, Arif O. ; Nowilaty, Sawsan R. ; Edward, Deepak P. ; Kozak, Igor</creator><creatorcontrib>Al Rashaed, Saba ; Khan, Arif O. ; Nowilaty, Sawsan R. ; Edward, Deepak P. ; Kozak, Igor</creatorcontrib><description>Purpose
To determine the relationship between prelaminar structural changes of the optic nerve head (ONH) and optic nerve waxy pallor in retinitis pigmentosa (RP) using spectral-domain optical coherence tomography (SD-OCT) and fundus photography.
Methods
An observational cross-sectional case control study of patients with RP with and without ONH waxy pallor and controls. Subjects underwent clinical examination, fundus photography, and SD-OCT raster imaging of the ONH. Four independent specialists reviewed the images in a masked fashion.
Results
Fifty-five eyes of 31 subjects with RP and 28 eyes of 14 controls were included. Optic nerve head waxy pallor was seen in 29 RP eyes (52.7 %) and none in controls. SD-OCT showed a hyper-reflective structure suggestive of a glial membrane-like structure on the surface of ONH in 16 of RP eyes (55.1 %). In the RP group, there was a significant positive correlation between the ONH pallor and the presence of a prelaminar structure (
p
= 0.006).
Conclusions
There is a presence of glial membrane-like structures on the optic nerve head surface in eyes with RP compared to healthy eyes. As the presence of glial membranes correlated with the presence of ONH waxy pallor, in such cases these membranes might be responsible for ONH waxy pallor.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-015-3015-1</identifier><identifier>PMID: 25900815</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Aged ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroglia - pathology ; Ophthalmology ; Optic Disk - pathology ; Optic Nerve Diseases - diagnosis ; Retinal Disorders ; Retinitis Pigmentosa - diagnosis ; Tomography, Optical Coherence ; Young Adult</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2016-01, Vol.254 (1), p.77-81</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-3e457f690fa97c41e6ca1d164a0241785b6f3c7c52eaaa8e622ccafbae17cb583</citedby><cites>FETCH-LOGICAL-c475t-3e457f690fa97c41e6ca1d164a0241785b6f3c7c52eaaa8e622ccafbae17cb583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25900815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al Rashaed, Saba</creatorcontrib><creatorcontrib>Khan, Arif O.</creatorcontrib><creatorcontrib>Nowilaty, Sawsan R.</creatorcontrib><creatorcontrib>Edward, Deepak P.</creatorcontrib><creatorcontrib>Kozak, Igor</creatorcontrib><title>Spectral-domain optical coherence tomography reveals prelaminar membranes in optic nerve head pallor in eyes with retinitis pigmentosa</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To determine the relationship between prelaminar structural changes of the optic nerve head (ONH) and optic nerve waxy pallor in retinitis pigmentosa (RP) using spectral-domain optical coherence tomography (SD-OCT) and fundus photography.
Methods
An observational cross-sectional case control study of patients with RP with and without ONH waxy pallor and controls. Subjects underwent clinical examination, fundus photography, and SD-OCT raster imaging of the ONH. Four independent specialists reviewed the images in a masked fashion.
Results
Fifty-five eyes of 31 subjects with RP and 28 eyes of 14 controls were included. Optic nerve head waxy pallor was seen in 29 RP eyes (52.7 %) and none in controls. SD-OCT showed a hyper-reflective structure suggestive of a glial membrane-like structure on the surface of ONH in 16 of RP eyes (55.1 %). In the RP group, there was a significant positive correlation between the ONH pallor and the presence of a prelaminar structure (
p
= 0.006).
Conclusions
There is a presence of glial membrane-like structures on the optic nerve head surface in eyes with RP compared to healthy eyes. As the presence of glial membranes correlated with the presence of ONH waxy pallor, in such cases these membranes might be responsible for ONH waxy pallor.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroglia - pathology</subject><subject>Ophthalmology</subject><subject>Optic Disk - pathology</subject><subject>Optic Nerve Diseases - diagnosis</subject><subject>Retinal Disorders</subject><subject>Retinitis Pigmentosa - diagnosis</subject><subject>Tomography, Optical Coherence</subject><subject>Young Adult</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAURi0EokPLA7BBltiwCfX1T5xZogpapEosSqXuohvPzYyrOA52pmhegOfG0bQIISE29uKe71jXH2NvQHwAIex5FkKDrQSYSi0HPGMr0MpUVsi752wlrISqUfLuhL3K-V4UXBl4yU6kWQvRgFmxnzcTuTnhUG1iQD_yOM3e4cBd3FGi0RGfY4jbhNPuwBM9EA6ZT4kGDH7ExAOFLuFImT-F-UjpgfiOcMMnHIaYlhEdCvLDz7simf3oZ180fhtonGPGM_aiL2J6_XifstvPn75dXFXXXy-_XHy8rpy2Zq4UaWP7ei16XFungWqHsIFao5DlJxrT1b1y1hlJiNhQLaVz2HdIYF1nGnXK3h-9U4rf95TnNvjsaBjKBnGfW2iUVVKrRv4ftUaLRoNSBX33F3of92ksiyyUgkZbsVBwpFyKOSfq2yn5gOnQgmiXPttjn22psl36bKFk3j6a912gze_EU4EFkEcgl9G4pfTH0_-0_gLhIa1j</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Al Rashaed, Saba</creator><creator>Khan, Arif O.</creator><creator>Nowilaty, Sawsan R.</creator><creator>Edward, Deepak P.</creator><creator>Kozak, Igor</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160101</creationdate><title>Spectral-domain optical coherence tomography reveals prelaminar membranes in optic nerve head pallor in eyes with retinitis pigmentosa</title><author>Al Rashaed, Saba ; Khan, Arif O. ; Nowilaty, Sawsan R. ; Edward, Deepak P. ; Kozak, Igor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-3e457f690fa97c41e6ca1d164a0241785b6f3c7c52eaaa8e622ccafbae17cb583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuroglia - pathology</topic><topic>Ophthalmology</topic><topic>Optic Disk - pathology</topic><topic>Optic Nerve Diseases - diagnosis</topic><topic>Retinal Disorders</topic><topic>Retinitis Pigmentosa - diagnosis</topic><topic>Tomography, Optical Coherence</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al Rashaed, Saba</creatorcontrib><creatorcontrib>Khan, Arif O.</creatorcontrib><creatorcontrib>Nowilaty, Sawsan R.</creatorcontrib><creatorcontrib>Edward, Deepak P.</creatorcontrib><creatorcontrib>Kozak, Igor</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al Rashaed, Saba</au><au>Khan, Arif O.</au><au>Nowilaty, Sawsan R.</au><au>Edward, Deepak P.</au><au>Kozak, Igor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spectral-domain optical coherence tomography reveals prelaminar membranes in optic nerve head pallor in eyes with retinitis pigmentosa</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>254</volume><issue>1</issue><spage>77</spage><epage>81</epage><pages>77-81</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To determine the relationship between prelaminar structural changes of the optic nerve head (ONH) and optic nerve waxy pallor in retinitis pigmentosa (RP) using spectral-domain optical coherence tomography (SD-OCT) and fundus photography.
Methods
An observational cross-sectional case control study of patients with RP with and without ONH waxy pallor and controls. Subjects underwent clinical examination, fundus photography, and SD-OCT raster imaging of the ONH. Four independent specialists reviewed the images in a masked fashion.
Results
Fifty-five eyes of 31 subjects with RP and 28 eyes of 14 controls were included. Optic nerve head waxy pallor was seen in 29 RP eyes (52.7 %) and none in controls. SD-OCT showed a hyper-reflective structure suggestive of a glial membrane-like structure on the surface of ONH in 16 of RP eyes (55.1 %). In the RP group, there was a significant positive correlation between the ONH pallor and the presence of a prelaminar structure (
p
= 0.006).
Conclusions
There is a presence of glial membrane-like structures on the optic nerve head surface in eyes with RP compared to healthy eyes. As the presence of glial membranes correlated with the presence of ONH waxy pallor, in such cases these membranes might be responsible for ONH waxy pallor.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25900815</pmid><doi>10.1007/s00417-015-3015-1</doi><tpages>5</tpages></addata></record> |
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| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2016-01, Vol.254 (1), p.77-81 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | Springer Link |
| subjects | Adolescent Adult Aged Case-Control Studies Child Cross-Sectional Studies Female Humans Male Medicine Medicine & Public Health Middle Aged Neuroglia - pathology Ophthalmology Optic Disk - pathology Optic Nerve Diseases - diagnosis Retinal Disorders Retinitis Pigmentosa - diagnosis Tomography, Optical Coherence Young Adult |
| title | Spectral-domain optical coherence tomography reveals prelaminar membranes in optic nerve head pallor in eyes with retinitis pigmentosa |
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