Positive feedback role of TRPC3 in TNF-α-mediated vasogenic edema formation induced by status epilepticus independent of ETB receptor activation

Highlights • TRPC3 was up-regulated during vasogenic edema formation induced by SE. • sTNFp55R and SN50 (but not BQ-788) inhibited up-regulated TRPC3 expression following SE. • Pyr-3 ameliorated SE-induced NFκB p65-Thr485 phosphorylation and ETB receptor expression. • Pyr-3 also mitigated NFκB p65-T...

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Bibliographic Details
Published in:Neuroscience 2016-11, Vol.337, p.37-47
Main Authors: Min, Su-Ji, Kang, Tae-Cheon
Format: Article
Language:English
Subjects:
ET-1
Neurology
NFκB
Pyr-3
status epilepticus
TNF-α
TRPC3
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Summary:Highlights • TRPC3 was up-regulated during vasogenic edema formation induced by SE. • sTNFp55R and SN50 (but not BQ-788) inhibited up-regulated TRPC3 expression following SE. • Pyr-3 ameliorated SE-induced NFκB p65-Thr485 phosphorylation and ETB receptor expression. • Pyr-3 also mitigated NFκB p65-Thr485 phosphorylation induced by recombinant TNF-α. • TRPC3 may be involved in a positive feedback loop of ETB receptor and NFκB signaling pathway.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.09.005