Triclosan elevates estradiol levels in serum and tissues of cycling and peri-implantation female mice

•We examined the effect of triclosan on estradiol concentrations in female mice.•Triclosan exposure increased the presence in tissues of exogenous 3H-estradiol.•Triclosan exposure produced elevated urinary estradiol concentrations.•These data may be pertinent to anti-reproductive and carcinogenic ef...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2016-10, Vol.65, p.394-401
Main Authors: Pollock, Tyler, Greville, Lucas J., Tang, Brandon, deCatanzaro, Denys
Format: Article
Language:English
Subjects:
Animals
Embryo Implantation
Estradiol
Estradiol - blood
Estradiol - pharmacokinetics
Estradiol - urine
Estrogens
Estrogens - blood
Estrogens - pharmacokinetics
Estrogens - urine
Female
Mice
Sulfotransferase
Tissue Distribution
Triclosan
Triclosan - toxicity
Uterus
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Summary:•We examined the effect of triclosan on estradiol concentrations in female mice.•Triclosan exposure increased the presence in tissues of exogenous 3H-estradiol.•Triclosan exposure produced elevated urinary estradiol concentrations.•These data may be pertinent to anti-reproductive and carcinogenic effects. Triclosan, an antimicrobial agent added to personal care products, can modulate estrogenic actions. We investigated whether triclosan affects concentrations of exogenous and endogenous estradiol. Female mice were given injections of triclosan followed by 1μCi tritium-labeled estradiol. Mice given daily 2-mg triclosan doses (57.9mg/kg/dose) showed significantly elevated radioactivity in tissues and serum compared to controls. A single dose of 1 or 2mg triclosan increased radioactivity in the uterus in both cycling and peri-implantation females. We also measured natural urinary estradiol at 2–12h following triclosan injection. Unconjugated estradiol was significantly elevated for several hours following 1 or 2mg of triclosan. These data are consistent with evidence that triclosan inhibits sulfonation of estrogens by interacting with sulfotransferases, preventing metabolism of these steroids into biologically inactive forms. Elevation of estrogen concentrations by triclosan is potentially relevant to anti-reproductive and carcinogenic actions of excessive estrogen activity.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2016.09.004