Detection of small subendocardial infarction using speckle tracking echocardiography in a rat model

Background It is challenging to detect small nontransmural infarcts visually or automatically. As it is important to detect myocardial infarction (MI) at early stages, we tested the hypothesis that small nontransmural MI can be detected using speckle tracking echocardiography (STE) at the acute stag...

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Bibliographic Details
Published in:Echocardiography (Mount Kisco, N.Y.) N.Y.), 2016-10, Vol.33 (10), p.1571-1578
Main Authors: Bachner-Hinenzon, Noa, Shlomo, Liron, Khamis, Hanan, Ertracht, Offir, Vered, Zvi, Malka, Assaf, Binah, Ofer, Adam, Dan
Format: Article
Language:English
Subjects:
Animals
Echocardiography - methods
Elasticity Imaging Techniques - methods
Endocardium - diagnostic imaging
myocardial infarction
Myocardial Infarction - complications
Myocardial Infarction - diagnostic imaging
myocardial strain
Myocardial Stunning - diagnostic imaging
Myocardial Stunning - etiology
Rats
Reproducibility of Results
Sensitivity and Specificity
stunning
viability
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Summary:Background It is challenging to detect small nontransmural infarcts visually or automatically. As it is important to detect myocardial infarction (MI) at early stages, we tested the hypothesis that small nontransmural MI can be detected using speckle tracking echocardiography (STE) at the acute stage. Methods Minimal nontransmural infarcts were induced in 18 rats by causing recurrent ischemia–reperfusion of the left anterior descending (LAD) coronary artery, followed by a 30‐min ligation and by reperfusion. A week later, the scar size was measured by histological analysis. Each rat underwent three echocardiography measurements: at baseline, 1 day post‐MI, and 1 week post‐MI. To measure the peak circumferential strain (CS), peak systolic CS, radial strain (RS), and time‐to‐peak (TTP) of the CS, short‐axis view of the apex was analyzed by a STE program. The TTP was normalized by the duration of the heart cycle to create percent change of heart cycle. Results Histological analysis after 1 week showed scar size of 4±6% at the anterior wall. At 24 h post‐MI, the peak CS, peak systolic CS, and RS were reduced compared to baseline at the anterior wall due to the MI, and at the adjacent segments—the anterior septum and lateral wall, due to stunning (P
ISSN:0742-2822
1540-8175
DOI:10.1111/echo.13291