Abstract 4957: Keratin 13 drives the dissemination of bone and brain metastases of human prostate and breast cancer cells

Introduction and Objective: Bone and brain metastases are prevalent in human prostate and breast cancer patients. Keratin 13 (KRT13), a member of the intermediate filament proteins and an epithelial stem cell differentiation marker, induces cancer cell migration and progression toward increased mali...

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Published in:Cancer research (Chicago, Ill.) Ill.), 2016-07, Vol.76 (14_Supplement), p.4957-4957
Main Authors: Yin, Lijuan, Li, Qinlong, Huang, Jen-Ming, Lewis, Michael, Garraway, Isla P., Li, Quanlin, Bu, Hong, Chung, Leland W. K, Zhau, Haiyen E.
Format: Article
Language:English
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Summary:Introduction and Objective: Bone and brain metastases are prevalent in human prostate and breast cancer patients. Keratin 13 (KRT13), a member of the intermediate filament proteins and an epithelial stem cell differentiation marker, induces cancer cell migration and progression toward increased malignant state. The objectives of this study are: 1) to determine KRT13 expression in human prostate and breast cancer and its clinical correlation; 2) to determine the functional cell signaling role of KRT13 in prostate and breast cancer cells using gene transfer technology. Methods and Results: We evaluated KRT13 protein expression in primary prostate cancer tissues from 44 cases with well-documented overall survival by quantitative quantum dot immuno-labelling. We found that KRT13 expression in primary prostate cancer correlated with patient overall survival and bone metastasis (p
ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM2016-4957