Molecular assessment of vitamin D receptor polymorphism as a valid predictor to the response of interferon/ribavirin-based therapy in Egyptian patients with chronic hepatitis C

Objective The aim of this study was to find an association between serum concentration of vitamin D and vitamin D receptor (VDR) polymorphisms to achieve a sustained virological response (SVR). Methods We conducted a case‐control study in which 250 participants were recruited and divided into three...

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Bibliographic Details
Published in:Journal of digestive diseases 2016-08, Vol.17 (8), p.547-553
Main Authors: Abdelsalam, Ahmed, Rashed, Laila, Salman, Tarek, Hammad, Lamiaa, Sabry, Dina
Format: Article
Language:English
Subjects:
Adult
Antiviral Agents - therapeutic use
Biomarkers - blood
Case-Control Studies
Drug Combinations
Female
Gene Frequency
Haplotypes
Hepatitis
Hepatitis C virus
Hepatitis C, Chronic - blood
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - genetics
Hepatitis C, Chronic - virology
Humans
Interferon
interferons
Interferons - therapeutic use
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Calcitriol - genetics
ribavirin
Ribavirin - therapeutic use
single nucleotide polymorphism
Sustained Virologic Response
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
vitamin D receptor
Young Adult
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Summary:Objective The aim of this study was to find an association between serum concentration of vitamin D and vitamin D receptor (VDR) polymorphisms to achieve a sustained virological response (SVR). Methods We conducted a case‐control study in which 250 participants were recruited and divided into three groups (100 chronic hepatitis C [CHC] patients who achieved SVR, 100 CHC patients who did not achieve SVR and 50 apparently healthy individuals as controls). Blood samples were collected to measure serum vitamin D concentration, and four VDR polymorphisms (FokI, ApaI, TaqI, and BsmI) were detected using polymerase chain reaction‐restriction fragment length polymorphism. Results Non‐responders were found to have significantly low vitamin D concentration compared with responders and control groups. Concerning VDR polymorphisms, both FokI and TaqI polymorphisms were associated with successful treatment. Conclusion Vitamin D concentration, FokI, and TaqI may be considered as the predictors for the response of CHC patients to a combination therapy of pegylated interferon and ribavirin.
ISSN:1751-2972
1751-2980
DOI:10.1111/1751-2980.12353