Oxidative stress parameters in localized scleroderma patients

Localized scleroderma (LS) (morphea) is a chronic, inflammatory skin disease with unknown cause that progresses with sclerosis in the skin and/or subcutaneous tissues. Its pathogenesis is not completely understood. Oxidative stress is suggested to have a role in the pathogenesis of localized sclerod...

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Bibliographic Details
Published in:Archives of Dermatological Research 2016-11, Vol.308 (9), p.625-629
Main Authors: Kilinc, F., Sener, S., Akbaş, A., Metin, A., Kirbaş, S., Neselioglu, S., Erel, O.
Format: Article
Language:English
Subjects:
Adult
Aged
Antioxidants - analysis
Aryldialkylphosphatase - blood
Carboxylic Ester Hydrolases - blood
Dermatology
Female
Healthy Volunteers
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Original Paper
Oxidative Stress
Scleroderma, Localized - blood
Scleroderma, Localized - metabolism
Scleroderma, Localized - physiopathology
Young Adult
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Summary:Localized scleroderma (LS) (morphea) is a chronic, inflammatory skin disease with unknown cause that progresses with sclerosis in the skin and/or subcutaneous tissues. Its pathogenesis is not completely understood. Oxidative stress is suggested to have a role in the pathogenesis of localized scleroderma. We have aimed to determine the relationship of morphea lesions with oxidative stress. The total oxidant capacity (TOC), total antioxidant capacity (TAC), paroxonase (PON) and arylesterase (ARES) activity parameters of PON 1 enzyme levels in the serum were investigated in 13 LS patients (generalized and plaque type) and 13 healthy controls. TOC values of the patient group were found higher than the TOC values of the control group ( p  
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-016-1682-3