Perenosins: a new class of anion transporter with anti-cancer activity

A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl − /NO 3 − antiporters and HCl cotrans...

Full description

Saved in:
Bibliographic Details
Published in:Organic & biomolecular chemistry 2016-01, Vol.14 (9), p.2645-265
Main Authors: Van Rossom, Wim, Asby, Daniel J, Tavassoli, Ali, Gale, Philip A
Format: Article
Language:English
Subjects:
Anions - metabolism
Antineoplastic Agents, Phytogenic - chemical synthesis
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antiporters - chemical synthesis
Antiporters - chemistry
Antiporters - pharmacology
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Crystallography, X-Ray
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Imines - chemistry
Indoles - chemistry
Indoles - pharmacology
Ion Transport - drug effects
MCF-7 Cells
Models, Molecular
Molecular Structure
Pyrroles - chemical synthesis
Pyrroles - chemistry
Pyrroles - pharmacology
Structure-Activity Relationship
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl − /NO 3 − antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7. A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported.
ISSN:1477-0520
1477-0539
DOI:10.1039/c6ob00002a