Prognostic significance of metabolic tumor volume in patients with piriform sinus carcinoma treated by radiotherapy with or without concurrent chemotherapy

Background The purpose of this study was to elucidate the prognostic significance of the pretreatment metabolic tumor volume (MTV) in patients with piriform sinus carcinoma treated by radiation‐based therapy. Methods This retrospective study included 100 patients with piriform sinus carcinomas who h...

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Published in:Head & neck 2016-11, Vol.38 (11), p.1666-1671
Main Authors: Yabuki, Kenichiro, Sano, Daisuke, Shiono, Osamu, Arai, Yasuhiro, Takahashi, Hideaki, Chiba, Yoshihiro, Tanabe, Teruhiko, Nishimura, Goshi, Takahashi, Masahiro, Taguchi, Takahide, Kaneta, Tomohiro, Hata, Masaharu, Oridate, Nobuhiko
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Chemoradiotherapy
concurrent chemoradiotherapy
Disease-Free Survival
Female
Humans
Hypopharyngeal Neoplasms - drug therapy
Hypopharyngeal Neoplasms - mortality
Hypopharyngeal Neoplasms - pathology
Hypopharyngeal Neoplasms - radiotherapy
Kaplan-Meier Estimate
metabolic tumor volume
Middle Aged
piriform sinus carcinoma
Positron-Emission Tomography
Prognosis
Pyriform Sinus - pathology
radiotherapy
Retrospective Studies
ROC Curve
survival
Tumor Burden
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Summary:Background The purpose of this study was to elucidate the prognostic significance of the pretreatment metabolic tumor volume (MTV) in patients with piriform sinus carcinoma treated by radiation‐based therapy. Methods This retrospective study included 100 patients with piriform sinus carcinomas who had received treatment by radiation‐based therapy. The MTV values were obtained from pretreatment positron emission tomography (PET). The association between clinical factors, including the MTV, and survival was analyzed. Results Kaplan–Meier estimates revealed the 5‐year disease‐free survival (DFS) rates were significantly poorer for patients with a high MTV compared to those with a low MTV. In the multivariate analysis, MTV (p < .001), nodal metastasis (p = .011), and applied chemotherapy regimen (p = .004) were found to be independent prognostic factors for DFS. Conclusion The locoregional MTV is a prognostic factor for DFS in patients with piriform sinus carcinoma treated by radiation‐based therapy. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708–1716, 2016
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.24488