Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke: e0141571

Background CT perfusion (CTP) is used to estimate the extent of ischemic core and penumbra in patients with acute ischemic stroke. CTP reliability, however, is limited. This study aims to identify regions misclassified as ischemic core on CTP, using infarct on follow-up noncontrast CT. We aim to ass...

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Bibliographic Details
Published in:PloS one 2015-11, Vol.10 (11)
Main Authors: Geuskens, R EG, Borst, Jordi, Lucas, Marit, Boers, A MMerel, Berkhemer, Olvert A, Roos, W EM, Walderveen, A Avan, Jenniskens, Sjoerd FM, Zwam, Wim Hvan, Dippel, Diederik WJ
Format: Article
Language:English
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Summary:Background CT perfusion (CTP) is used to estimate the extent of ischemic core and penumbra in patients with acute ischemic stroke. CTP reliability, however, is limited. This study aims to identify regions misclassified as ischemic core on CTP, using infarct on follow-up noncontrast CT. We aim to assess differences in volumetric and perfusion characteristics in these regions compared to areas that ended up as infarct on follow-up. Materials and Methods This study included 35 patients with >100 mm brain coverage CTP. CTP processing was performed using Philips software (IntelliSpace 7.0). Final infarct was automatically segmented on follow-up noncontrast CT and used as reference. CTP and follow-up noncontrast CT image data were registered. This allowed classification of ischemic lesion agreement (core on CTP: rMTT greater than or equal to 145%, aCBV
ISSN:1932-6203
DOI:10.1371/journal.pone.0141571